Manipulation of MHC-I/TCR Interaction for Immune Therapy

被引：0

作者：

Qingjun Liu1

2Institute of Microbiology

机构：

来源：

Cellular&MolecularImmunology | 2008年 / 03期

关键词：

MHC-I; TCR; MHC-I/TCR interaction; immune therapy;

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Adoptive immunotherapy involving the transfer of autologous tumor or virus-reactive T lymphocytes has been demonstrated to be effective in the eradication of cancer and virally infected cells. Identification of MHC-restricted antigens and progress in generation of adaptive immune responses have provided new direction for such treatment for severe pathologies such as cancer and autoimmune diseases. Here we review the latest development about the molecular basis of MHC-I/TCR interaction, and its manipulation including enhanced MHC-I expression, modification of peptide and engineered TCR for clinical applications such as vaccine design, tumor therapy and autoimmune diseases.

引用

页码：171 / 182

页数：12

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