肝素结合蛋白与感染相关的研究进展

被引:12
|
作者
孙玲玲 [1 ]
蔡国龙 [2 ]
严静 [2 ]
机构
[1] 浙江中医药大学第二临床医学院
[2] 浙江医院重症医学科
关键词
肝素结合蛋白; 感染; 脓毒症; 诊断; 血管通透性;
D O I
暂无
中图分类号
R446 [实验室诊断];
学科分类号
100208 ;
摘要
肝素结合蛋白(HBP)的功能多样,其可以激活单核细胞和巨噬细胞,有显著的抗菌活性、趋化特性及调节炎症反应作用;还可以修饰内皮细胞,导致血管泄漏,促进白细胞从毛细血管迁移到感染部位,并可以增加血管通透性。HBP参与疾病的病理生理过程,在血管通透性改变中发挥关键作用。HBP诊断性能作为一种生物标志物,以及潜在的使用HBP作为治疗的目标。本文综述HBP的结构和功能,辅助疾病诊断如早期呼吸循环衰竭、泌尿系统感染、细菌性皮肤感染、细菌性脑膜炎、早期脓毒症、儿童尿路感染、急性细菌性脑膜炎及作为治疗调节目标等方面的研究进展,为感染疾病的诊治提供新的手段。
引用
收藏
页码:148 / 152
页数:5
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