5'CpG Island Hypermethylation of p16 Gene in Gynecologic Malignancy

被引:0
作者
Xu Bing
机构
关键词
Hypermethylation; Genes; p16; 5’ CPG island; Gynecologic malignancy;
D O I
10.13283/j.cnki.xdfckjz.2000.01.045
中图分类号
R363 [病理生理学];
学科分类号
100104 ;
摘要
Objective:To study the role of hypermethylation of 5’ CpG island of p16 gene in arcinogenesis and progression of gynecologic malignancy. Methods: PCR-based analysis was performed to detect the hypermethylation of 5’ CpG island of exon 1 in p16 gene in ervical,endometrial and ovarian carcinomas and corresponding normal tissues. Results: ypermethylation of p16 gene was detected in 6 of 30 cervical, 8 of 34 endometrial, 4 of 30 ovarian carcinomas respectively. Hypermethylation of p16 gene in cervical and endornetrial carcinomas was significantly higher at late stage(Ⅲ-Ⅳ )and low grade than that at early stage(Ⅰ-Ⅱ )and high grade. Conclusions: Hypermethylation of pl6 gene may play an important role in carcinogenesis and progression of gynecologic malignancy.
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页码:77 / 79
页数:3
相关论文
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  • [1] Serrano M,Hannon GJ,Beach D.A new regulatory motifin cell-cycle control causing specific inhibibtion of cyclin D/cdk4. Nature . 1993
  • [2] Herman JG,Merlo A,Mao L,et al.Inactivation of theDNKN2/p16/MST1 gene is frequently associated with abberant DNA methylation in all common human cancers. Cancer Research . 1995
  • [3] Kamb A,Gruis N A,Weaver F J,et al.A cell cycle regulatorpotentially involved in genesis of many tumor types. Science . 1994
  • [4] Fujita M,Enomoto T,Haba T.Alteration of p16 and p15genes in common epithelial ovarian tumors. International Journal of Cancer . 1997