SynthesesandAnti-inflammatoryActionof（η-C5H5）2Ti（Cin）2and（η-C5H5）2Ti（Tzea）2

被引：0
作者：
曾正志
机构：
来源：
Chinese Journal of Chemistry | 2002年 / 05期
关键词：
cyclopentadienyltitanium; complexes; anti inflammatory;
D O I：
暂无
中图分类号：
O641 [结构化学];
学科分类号：
070304 ; 081704 ;
摘要：
Two new complexes (Cp) 2Ti(Cin) 2 and (Cp) 2Ti(Tzea) 2 (Cp= Cyclopentadienyl η 5 C 5H 5) have been synthesized in THF by the reaction of HCin (Cincofen, 2 phenylquinoline 4 carboxylic acid) or HTzea (5 phenyltetrazolyl 2 ethanoic acid) with (Cp) 2TiCl 2, and characterized by elemental analyses, IR, 1H NMR and 13 C NMR, UV spectra, molar conductivity, TG DTA. In the complexes the carboxyl groups are coordinated to Ti(IV) in a monodentate manner. The inhibitory actions of the complexes on mice ear tumefaction caused by croton oil and the rat foot granulation growth produced by cotton wool are higher than those of the corresponding ligands HCin, HTzea and [(Cp) 2TiCl 2], while their toxicities are lower than those of the free ligands.
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页码：474 / 478
页数：5
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