SynthesesandAnti-inflammatoryActionof（η-C5H5）2Ti（Cin）2and（η-C5H5）2Ti（Tzea）2

被引：0

作者：

曾正志

机构：

来源：

Chinese Journal of Chemistry | 2002年 / 05期

关键词：

cyclopentadienyltitanium; complexes; anti inflammatory;

D O I：

暂无

中图分类号：

O641 [结构化学];

学科分类号：

070304 ; 081704 ;

摘要：

Two new complexes (Cp) 2Ti(Cin) 2 and (Cp) 2Ti(Tzea) 2 (Cp= Cyclopentadienyl η 5 C 5H 5) have been synthesized in THF by the reaction of HCin (Cincofen, 2 phenylquinoline 4 carboxylic acid) or HTzea (5 phenyltetrazolyl 2 ethanoic acid) with (Cp) 2TiCl 2, and characterized by elemental analyses, IR, 1H NMR and 13 C NMR, UV spectra, molar conductivity, TG DTA. In the complexes the carboxyl groups are coordinated to Ti(IV) in a monodentate manner. The inhibitory actions of the complexes on mice ear tumefaction caused by croton oil and the rat foot granulation growth produced by cotton wool are higher than those of the corresponding ligands HCin, HTzea and [(Cp) 2TiCl 2], while their toxicities are lower than those of the free ligands.

引用

收藏

页码：474 / 478

页数：5

相关论文

共 50 条

[21] Mechanochemical C-H bond activation: Synthesis of the tuckover hydrides, (C5Me5)2Ln(μ-H)(μ-η1: η5-CH2C5Me4)Ln(C5Me5) from solvent-free reactions of (C5Me5)2Ln(μ-Ph)2BPh2 with KC5Me5 [J].

Woen, David H. ;

White, Jessica R. K. ;

Ziller, Joseph W. ;

Evans, William J. .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2019, 899

[22] Synthesis and Electrochemical Behavior of Ferrocenyl-Functionalized Metallocenes M(5-C5H5)2(EFc)2 (M = Ti, Zr; E = O, S, Se) [J].

Frenzel, Peter ;

Korb, Marcus ;

Hildebrandt, Alexander ;

Lang, Heinrich .

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2018, (27) :3156-3163

[23] Photoinduced rearrangements of ring-coupled bis(cyclopentadienylrutheniumdicarbonyl) compounds of the form Ru-2(CO)(4)(eta(5),eta(5)-C(5)H(4)LC(5)H(4)) (L=CH2-, (CH3)(2)C-, C2H4- and (CH3)(2)Si-) - The molecular structure of [Ru(CO)(2)][Ru(CO)(2)Cl](eta(5),eta(5):eta(1)-C5H4CH2C5H3) [J].

Bitterwolf, TE ;

Shade, JE ;

Hansen, JA ;

Rheingold, AL .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 1996, 514 (1-2) :13-21

[24] Chlorido(η5-cyclopentadienyl)bis-(dimethylamido)titanium, [TiCl(η5-C5H5)(NMe2)2] [J].

Chapin, Brette M. ;

Hughs, Lauren D. ;

Golen, James A. ;

Rheingold, Arnold L. ;

Johnson, Adam R. .

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2010, 66 :M191-M193

[25] Ti(η5-1-SiMe3-C9H6)(Cl)2(OR): Structure and bonding [J].

Taher, Deeb ;

Klaib, Sami ;

Awwadi, Firas F. ;

Helal, Wissam ;

Gharaibeh, Mohammed ;

Rheinwald, Gerd ;

Rueffer, Tobias ;

Lang, Heinrich .

INORGANICA CHIMICA ACTA, 2018, 477 :270-276

[26] Reactions of diferrocenyl dichalcogenides with [W(CO)5(THF)]:: X-ray crystal structures of Fc2Te2 and [W2(μ-SeFc)2(CO)8] (Fc=[Fe(η5-C5H5)(η5-C5H4)]) [J].

Burgess, Mark R. ;

Jing, Su ;

Morley, Christopher P. ;

Thone, Carsten .

JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2006, 691 (23) :4963-4967

[27] The effect of [(η3-C3H5)(η5-C5H5)Mo(CO)2] on drying of solvent-borne alkyd paints [J].

Preininger, Ondrej ;

Honzicek, Jan ;

Vinklarek, Jarornir ;

Erben, Milan .

PROGRESS IN ORGANIC COATINGS, 2014, 77 (02) :292-297

[28] Hartree-Fock and density functional theory study of remote substituent effects on heterolytic Fe-C bond energies of p-G-C6H4CH2Fe(CO)2(η5-C5H5) and p-G-C6H4(H)(CN)CFe(CO)2(η5-C5H5) [J].

Zeng, Qing ;

Li, Zucheng .

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2012, 25 (01) :32-41

[29] Remote substituent effects on homolytic Fe-C bond energies of p-G-C6H4CH2Fe(CO)2 (η5-C5H5) and p-G-C6H4(H)(CN)CFe(CO)2 (η5-C5H5) studied by Hartree-Fock and density functional theory methods [J].

Zeng, Qing ;

Li, Zucheng .

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 2011, 24 (11) :1058-1066

[30] Nearly Perfect Spin Filter Based on a Wire of Half-Metallic (η5-C5H5)Ti(η8-C8H8)Ti Units [J].

Zhu, Sicong ;

Fang, Jianming ;

Yao, Kailun ;

Wu, Yanqing .

PHYSICAL REVIEW APPLIED, 2015, 4 (01)

← 1 2 3 4 5 →