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- [1] Metal binding by pharmaceuticals. part 2. interactions of Ca(II), Cu(II), Fe(II), Mg(II), Mn(II) and Zn(II) with the intracellular hydrolysis products of the antitumour agent ICRF 159 and its inactive homologue ICRF 192[J] . Zhong-Xian Huang,Peter M. May,Kevin M. Quinlan,David R. Williams,Andrew M. Creighton.Agents and Actions . 1982 (4)