Experimental Study of Multi-slice Spiral CT Perfusion Imaging in VX 2 Soft-tissue Tumor of Rabbits

被引：3

作者：

张景峰 ^{[1
]}

王仁法 ^{[2
]}

王敏 ^{[2
]}

李勇刚 ^{[2
]}

杨海涛 ^{[2
]}

机构：

[1] Department of Radiology, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China,Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030

来源：

华中科技大学学报(医学英德文版) | 2006年 / 03期

关键词：

computed tomography; perfusion imaging; soft-tissue tumor; experimental study;

D O I：

暂无

中图分类号：

R73-3 [肿瘤学实验研究];

学科分类号：

100214 ;

摘要：

An experimental animal model of malignant soft-tissue tumor was established to investigate the applied value of multi-slice spiral CT perfusion imaging preliminarily. Ten New Zealand white rabbits which were implanted with VX_ 2 tumor in either proximal thigh were subjected to CT plain scan and perfusion scan two weeks later respectively, then the original perfusion images were transmitted to AW4.0 Workstation. The functional maps and perfusion parameters including blood flow (BF), blood volume (BV), mean transit time (MTT) and permeability surface (PS) were computed and analyzed. All the values of BF, BV and PS in VX_ 2 soft-tissue tumors were obviously higher while the MTT-values were lower than those in the normal muscular tissues significantly. It was suggested that multi-slice spiral CT perfusion imaging is an accurate, convenient and relatively safe functional imaging technique, and can give a quantitative assessment to angiogenesis and blood perfusion of soft-tissue tumors.

引用

页码：341 / 343

页数：3