Antigenic variation of the human influenza A(H3N2) virus during the 2014–2015 winter season

被引：17

作者：

HUA Sha ^{[1
,2
]}

LI XiYan ^{[3
]}

LIU Mi ^{[1
,2
]}

CHENG YanHui ^{[3
]}

PENG YouSong ^{[4
]}

HUANG WeiJuan ^{[3
]}

TAN MinJu ^{[3
]}

WEI HeJiang ^{[3
]}

GUO JunFeng ^{[3
]}

WANG DaYan ^{[3
]}

WU AiPing ^{[1
,5
,6
]}

SHU YueLong ^{[3
]}

JIANG TaiJiao ^{[1
,4
,5
,6
]}

机构：

[1] Institute of Biophysics, Chinese Academy of Sciences

[2] University of the Chinese Academy of Sciences

[3] National Institute for Viral Disease Control and Prevention, China Center for Disease Control and Prevention

[4] College of Information Science and Engineering, Hunan University

[5] Center for Systems Medicine, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College

[6] Suzhou Institute of Systems Medicine

来源：

Science China(Life Sciences) | 2015年 / 09期

关键词：

influenza; H3N2; virus; antigenic evolution; antigenicity;

D O I：

暂无

中图分类号：

R511.7 [流行性感冒];

学科分类号：

100401 ;

摘要：

The human influenza A(H3N2) virus dominated the 2014–2015 winter season in many countries and caused massive morbidity and mortality because of its antigenic variation. So far, very little is known about the antigenic patterns of the recent H3N2 virus. By systematically mapping the antigenic relationships of H3N2 strains isolat ed since 2010, we discov ered that two groups with obvious antigenic divergence, named SW13(A/Switzerland/9715293/2013-like strains) and HK14(A/Hong Kong/5738/2014-like strains), co-circulated during the 2014–2015 winter season. HK14 group co-circulated with SW13 in Europe and the United States during this season, while there were few strains of HK14 in China's mainland, where SW13 has dominated since 2012. Furthermore, we found that substitutions near the receptor-binding site on hemagglutinin played an important role in the antigenic variation of both the groups. These findings provide a comprehensive understanding of the recent antigenic evolution of H3N2 virus and will aid in the selection of vaccine strains.

引用

页码：882 / 895

页数：14

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