Synthesis and Characterization of Magnetic SiO2 Nanoparticles Loaded with Naproxen for Anti-inflammatory Therapy

被引：0

作者：

杨晓霞 ^{[1
,2
]}

陈志龙 ^{[1
,2
]}

黄鹏 ^{[1
]}

周兴平 ^{[1
]}

机构：

[1] Key Laboratory of Textile Science & Technology of Eco-Textile,Ministry of Education,Donghua University

[2] College of Chemistry,Chemical Engineering and Biotechnology,Donghua University

来源：

Journal of Donghua University(English Edition) | 2010年 / 27卷 / 03期

基金：

中央高校基本科研业务费专项资金资助;

关键词：

magnetic; Naproxen; nanoparticle; drug delivery; Fe3O4;

D O I：

10.19884/j.1672-5220.2010.03.013

中图分类号：

TB383.1 [];

学科分类号：

070205 ; 080501 ; 1406 ;

摘要：

The aim of this study is to synthesize of magnetic SiO2 nanoparticles(MSNPs)loaded with Naproxen(NAP-MSNPs)for targeting anti-flammatory therapy.The Fe3O4 nanoparticles were coated with a thin layer of silica by stber method and the drug was encapsulated in it simultaneously.The optimal conditions were investigated for the synthesis of MSNPs.The shape,size,and phase structure of NAP-MSNP were characterized by transmission electron micrographs(TEM)and X-ray diffraction(XRD).The drug encapsulation efficiency was confirmed by FT-IR and measured by UV spectrometry.The NAP-MSNPs show the response at the external magnetic field and the drug could be released readily from NAP-MSNPs.All of these facts suggest the NAP-MSNPs could be applied in a promising drug release-controlling system for targeting anti-inflammatory therapy.

引用

页码：364 / 369

页数：6

共 10 条

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