Organophosphine bearing multiple hydrogen-bond donors for asymmetric Michael addition reaction of 1-oxoindane-2-carboxylic acid ester via dual-reagent catalysis

被引：0

作者：

Haoran Hong ^{[1
]}

Hongyu Wang ^{[2
]}

Changwu Zheng ^{[3
]}

Gang Zhao ^{[3
]}

Yongjia Shang ^{[1
]}

机构：

[1] Key Laboratory of Functionalized Molecular Solids,Ministry of Education,Anhui Key Laboratory of Malecule-Based Materials (State Key Laboratory Cultivation Base),College of Chemistry and Materials Science,Anhui Normal University

[2] College of Chemistry,Chemical Engineering and Materials Science,Shandong Normal University

[3] Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,Center for Excellence in Molecular Synthesis,Chinese Academy of Sciences

来源：

ChineseChemicalLetters | 2021年 / 32卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Dual-reagent catalysis; Michael addition reaction; Multiple hydrogen bonds; Chiral quaternary carbon centers;

D O I：

暂无

中图分类号：

O626 [杂环化合物];

学科分类号：

070303 ; 081704 ;

摘要：

Multiple hydrogen bonds containing nucleophilic phosphines derived from dipeptide dual-reagents catalyzed asymmetric Michael addition reactions between indene esters and activated olefins in high yields and good to excellent enantioselectivities under mild reaction conditions.The success of current highly selective reactions should provide inspiration for expansion to other reactions and would open up new paradigms for the synthesis of indanone derivatives bearing chiral quaternary carbon centers.

引用

页码：708 / 712

页数：5

共 3 条

[1] Organophosphine bearing multiple hydrogen-bond donors for asymmetric Michael addition reaction of 1-oxoindane-2-carboxylic acid ester via dual-reagent catalysis
Hong, Haoran
Wang, Hongyu
Zheng, Changwu
Zhao, Gang
Shang, Yongjia
CHINESE CHEMICAL LETTERS, 2021, 32 (02) : 708 - 712
[2] Organocatalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones with bifunctional amine-thiourea catalysts bearing multiple hydrogen-bond donors
Zhang, Ming-Liang
Yue, Deng-Feng
Wang, Zhen-Hua
Luo, Yuan
Xu, Xiao-Ying
Zhang, Xiao-Mei
Yuan, Wei-Cheng
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2016, 12 : 295 - 300
[3] Asymmetric Michael reaction of arylacetyl phosphonates to nitroalkenes with bifunctional amine-thiourea catalyst bearing multiple-hydrogen-bond donor: efficient construction of chiral α-substituted carboxylic ester compounds
Zhang, Ming-Liang
Chen, Lin
You, Yong
Wang, Zhen-Hua
Yue, Deng-Feng
Zhang, Xiao-Mei
Xu, Xiao-Ying
Yuan, Wei-Cheng
TETRAHEDRON, 2016, 72 (21) : 2677 - 2682

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