Two Cu(Ⅱ) Complexes with Hydrolyzed Nicotinamide Ligand: Crystal Structures and Bioactivities

被引：0

作者：

王仁舒 ^{[1
]}

冯静 ^{[1
]}

连明磊 ^{[1
]}

孔德顺 ^{[1
]}

雷以柱 ^{[1
]}

石开仪 ^{[1
]}

机构：

[1] School of Chemistry and Materials Engineering, Liupanshui Normal University

来源：

Chinese Journal of Structural Chemistry | 2019年 / 38卷 / 08期

关键词：

Cu(Ⅱ) complexes; Hirshfeld surface analysis; crystal structures; bioactivities;

D O I：

10.14102/j.cnki.0254-5861.2011-2252

中图分类号：

O641.4 [络合物化学（配位化学）];

学科分类号：

070304 ; 081704 ;

摘要：

Two Cu(Ⅱ) complexes of [Cu(2,6-DPC)(Hnta)(HO)]·HO(2,6-DPC = 2,6-pyridinedicarboxylic-carboxylate, Hnta = nicotinic acid) and [Cu(2,4-D)(Hnta)](2,4-D = 2,4-dichlorophenoxyacetic-carboxylate) were synthesized and successfully obtained as single crystals in this paper. The supramolecular structures of the complexes from zero to three dimensions and the weak intermolecular force in the crystal were analyzed. The single-crystal structures of the complexes were further analyzed by Hirshfeld surface analysis. The competition capacity of the complexes about calf thymus DNA(ct-DNA) was also analyzed by fluorescence spectroscopy. The ability of complexes to cleave the plasmid DNA(pBR322-DNA) was determined by gel electrophoresis assay. And at last, the complexes’ cytotoxic activities were reviewed for four kinds of cancer cell lines(HeLa, MCF-7, HepG, SKOV-3), showing that the coordination polymer has anti-tumor activity and cytotoxicity.

引用

页码：1297 / 1310

页数：14

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