Corneal alteration and pathogenesis in diabetes mellitus

被引：0

作者：

Han Zhao ^{[1
,2
]}

Yan He ^{[1
,2
]}

Yue-Rong Ren ^{[1
,2
]}

Bai-Hua Chen ^{[1
,2
]}

机构：

[1] Department of Ophthalmology, the Second Xiangya Hospital,Central South University

[2] Hunan Clinical Research Center of Ophthalmic Disease

来源：

International Journal of Ophthalmology | 2019年 / 12卷 / 12期

基金：

中国国家自然科学基金;

关键词：

diabetes mellitus; diabetic keratopathy; diabetic neuropathy; in vivo confocal microscopy; advanced glycation end products;

D O I：

暂无

中图分类号：

R587.2 [糖尿病性昏迷及其他并发症]; R772.2 [角膜疾病];

学科分类号：

1002 ; 100201 ; 100212 ;

摘要：

● The incidence of diabetes mellitus(DM) and its complications have increased considerably worldwide. Diabetic keratopathy is the major complication of the cornea characterized by delayed corneal wound healing, decreasing corneal epithelial sensitivity, and recurrent corneal ulcers. There is accumulating evidence that diabetic keratopathy is correlated with the hyperglycemic state. Different corneal components may produce different alterations under hyperglycemia. In addition, diabetic nerve alteration may become a novel biomarker of earlystage DM. Abnormalities of the corneal nerve plexus have been associated with diabetic inflammatory states. There is rapidly growing evidence based on investigations of diabetic corneal nerves through in vivo confocal microscopy. Understanding the molecular pathogenesis caused by hyperglycemia may assist in the identification of novel biomarkers, as well as therapeutic targets for early treatment. This review mainly summarizes recent findings on corneal alteration and pathogenesis in DM.

引用

页码：1939 / 1950

页数：12