双环醇对大鼠肾脏缺血-再灌注损伤的保护作用

被引：20
|
作者：
赵冬梅
孙韬
李燕
机构：
[1] 中国医学科学院、中国协和医科大学药物研究所
来源：
药学学报 | 2002年 / 06期
关键词：
双环醇; 缺血再灌注; 肾损伤;
D O I：
10.16438/j.0513-4870.2002.06.004
中图分类号：
R965 [实验药理学];
学科分类号：
摘要：
目的　观察双环醇对缺血 再灌注诱发肾损伤的保护作用。方法　在大鼠肾动脉缺血 再灌注模型上观察双环醇对肾缺血 再灌注引起的血清丙二醛 (MDA)、尿素氮 (BUN) ,肾脏还原型谷胱甘肽 (GSH)、谷胱甘肽巯基转移酶 (GST)及肾线粒体膜流动性改变的影响。结果　双环醇ig 5 0及 2 0 0mg·kg- 1 可剂量依赖性保护缺血 再灌注引起的血清MDA及BUN升高、肾GSH含量降低 ,同时可诱导GST活性 ,缓解由于缺血 再灌注损伤引起的线粒体膜流动性降低。结论　双环醇对肾缺血 再灌注损伤有保护作用
引用
收藏
页码：412 / 414
页数：3
相关论文
共 9 条
  • [1] Alterations of human erythrocyte membrane fluidity by oxygen-derived free radicals and calcium. Watanabe H, Kobayashi A, Yamamoto T, et al. Free Radical Biology and Medicine . 1990
  • [2] The involvement of oxidative stress in the progression of renal injury. Haugen E, Nath KA. Blood Purification . 1999
  • [3] A study of ginsenoside-Rd in a renalischemia-reperfusion model. Yokozawa T,Liu ZW,Dong E. Nephron . 1998
  • [4] Antioxidative vitamins in prevention of ischemia/reperfusion injury. Nagel E, Meyer zu Vilsendorf A, Bartels M, et al. International Journal for Vitamin and Nutrition Research . 1997
  • [5] Detection of in vivo lipid peroxidation using the thiobarbituric acid assay for lipid hydroperoxides. Kirkpatrick DT, Guth DJ, Mavis RD. Journal of Biochemical and Molecular Toxicology . 1986
  • [6] Postischemic renal injury due to oxygen radicals. Johnson KJ, Weinberg JM. Current Opinion in Nephrology and Hypertension . 1993
  • [7] Oxygen free radicals in ischemic acute renal failure in the rat. Paller MS, Hoidal JR, Ferris TF. The Journal of Clinical Investigation . 1984
  • [8] GutathioneS transferases. HabitWH ,PabstMJ,JakobyWB. Journal of Biochemistry . 1974
  • [9] Reactive oxygen species and acute renal failure. Nath KA, Norby SM. The American Journal of Medicine . 2000
1