Endoscopic diagnosis of cytomegalovirus gastritis after allogeneic hematopoietic stem cell transplantation

被引:0
作者
Yasuo Kakugawa [1 ]
Masahiro Kami [2 ]
Takahisa Matsuda [1 ]
Yutaka Saito [1 ]
Sung-Won Kim [3 ]
Takahiro Fukuda [3 ]
Shin-ichiro Mori [3 ]
Tadakazu Shimoda [4 ]
Ryuji Tanosaki [3 ]
Daizo Saito [1 ]
机构
[1] Division of Endoscopy, National Cancer Center Hospital(Japan)
[2] Division of Exploratory Research,Institute of Medical Science,University of Tokyo
[3] Division of Hematopoietic Stem Cell Transplantation,National Cancer Center Hospital(Japan)
[4] Clinical Laboratory Division,National Cancer Center Hospital(Japan)
关键词
Cytomegalovirus gastritis; Hematopoietic stem cell transplantation; Cytomegalovirus antigenemia; Esophagogastroduodenoscopy; Graft-versus-host disease;
D O I
暂无
中图分类号
R573.3 [胃炎];
学科分类号
1002 ; 100201 ;
摘要
AIM:To clarify the endoscopic and clinical findings of cytomegalovirus(CMV) gastritis after allogeneic hematopoietic stem cell transplantation(allo-SCT).METHODS:Between 1999 and 2005,523 patients underwent allo-SCT at our hospital,and 115 of these patients with gastrointestinal symptoms underwent esophagogastroduodenoscopy.RESULTS:CMV gastritis was diagnosed pathologically in seven patients(1.3%) with the other 108 patients serving as controls.Six of the seven patients developed positive CMV antigenemia,and five complained of abdominal pain.Development of abdominal pain preceded CMV antigenemia in four of the f ive patients.Endoscopic examination showed oozing(n=2),erosion(n=6),and redness(n=5) in the seven patients with CMV gastritis,while the control patients showed oozing(n=3),erosion(n=24),and redness(n=100).Erosion and oozing were more frequently documented in patients with CMV gastritis compared with the controls,and the differences were statistically significant(P=0.0012 and 0.029,respectively).CMV inclusion bodies were documented in 12 of 14 biopsy specimens obtained from erosive lesions,while they were identif ied in 4 of 15 biopsy specimens obtained from lesions other than erosions(P=0.0025).CONCLUSION:This study suggests that erosion and oozing,as well as abdominal pain,are useful indicators in the diagnosis of CMV gastritis following allo-SCT.
引用
收藏
页码:2907 / 2912
页数:6
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