Recent Advances of DNA Hydrogels in Biomedical Applications

被引:0
作者
HuaiQing Chen [1 ]
Wan Yang [1 ]
Hua Zuo [2 ]
HuaWei He [1 ,3 ,4 ]
YeJing Wang [1 ,3 ]
机构
[1] State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University
[2] College of Pharmaceutical Sciences, Southwest University
[3] Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University
[4] Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing
关键词
DNA hydrogels; Self-assembly; Biosensing; Drug carrier; Cancer therapy;
D O I
暂无
中图分类号
R318.08 [生物材料学]; TQ427.26 [];
学科分类号
0805 ; 080501 ; 080502 ; 0817 ;
摘要
DNA hydrogel is one of DNA-based nanomaterials with unique advantages such as precise self-assembly,programmability,addressability,high stability,excellent biocompatibility and biodegradability,and tunable versatility.These features have greatly promoted the development of DNA hydrogels in various applications,especially molecular diagnostics,biosensing,drug delivery,and cancer therapy.In this review,we briefly review the history of DNA hydrogels,the latest advances of DNA hydrogels in biomedical applications especially in biosensing,drug delivery and cancer therapy,and prospect the key challenges and future directions.
引用
收藏
页码:155 / 164
页数:10
相关论文
共 74 条
[61]   Alginate: Properties and biomedical applications [J].
Lee, Kuen Yong ;
Mooney, David J. .
PROGRESS IN POLYMER SCIENCE, 2012, 37 (01) :106-126
[62]   Cellular Immunostimulation by CpG-Sequence-Coated DNA Origami Structures [J].
Schueller, Verena J. ;
Heidegger, Simon ;
Sandholzer, Nadja ;
Nickels, Philipp C. ;
Suhartha, Nina A. ;
Endres, Stefan ;
Bourquin, Carole ;
Liedl, Tim .
ACS NANO, 2011, 5 (12) :9696-9702
[63]   Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides [J].
Li, Jiang ;
Pei, Hao ;
Zhu, Bing ;
Liang, Le ;
Wei, Min ;
He, Yao ;
Chen, Nan ;
Li, Di ;
Huang, Qing ;
Fan, Chunhai .
ACS NANO, 2011, 5 (11) :8783-8789
[64]  
DNAzyme crosslinked hydrogel: a new platform for visual detection of metal ions[J] . Lin Haoxue,Zou Yuan,Huang Yishun,Chen Jie,Zhang Wei Yun,Zhuang Zhixia,Jenkins Gareth,Yang Chaoyong James.Chemical communications (Cambridge, England) . 2011 (33)
[65]   Affinity hydrogels for controlled protein release using nucleic acid aptamers and complementary oligonucleotides [J].
Soontornworajit, Boonchoy ;
Zhou, Jing ;
Snipes, Matthew P. ;
Battig, Mark R. ;
Wang, Yong .
BIOMATERIALS, 2011, 32 (28) :6839-6849
[66]   Self-Assembled DNA Hydrogels with Designable Thermal and Enzymatic Responsiveness [J].
Xing, Yongzheng ;
Cheng, Enjun ;
Yang, Yang ;
Chen, Ping ;
Zhang, Tao ;
Sun, Yawei ;
Yang, Zhongqiang ;
Liu, Dongsheng .
ADVANCED MATERIALS, 2011, 23 (09) :1117-1121
[67]   Three-Dimensional Self-Assembly of Graphene Oxide and DNA into Multifunctional Hydrogels [J].
Xu, Yuxi ;
Wu, Qiong ;
Sun, Yiqing ;
Bai, Hua ;
Shi, Gaoquan .
ACS NANO, 2010, 4 (12) :7358-7362
[68]  
Biodegradable CpG DNA hydrogels for sustained delivery of doxorubicin and immunostimulatory signals in tumor-bearing mice[J] . Makiya Nishikawa,Yumiko Mizuno,Kohta Mohri,Nao Matsuoka,Sakulrat Rattanakiat,Yuki Takahashi,Hisakage Funabashi,Dan Luo,Yoshinobu Takakura.Biomaterials . 2010 (2)
[69]   Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists [J].
Kanzler, Holger ;
Barrat, Franck J. ;
Hessel, Edith M. ;
Coffman, Robert L. .
NATURE MEDICINE, 2007, 13 (05) :552-559
[70]   Enzyme-catalysed assembly of DNA hydrogel [J].
Um, Soong Ho ;
Lee, Jong Bum ;
Park, Nokyoung ;
Kwon, Sang Yeon ;
Umbach, Christopher C. ;
Luo, Dan .
NATURE MATERIALS, 2006, 5 (10) :797-801