DNA cleavage mediated by water-soluble manganese corrole

被引：0
|
作者：
Jun Lu~a
机构：
来源：
Chinese Chemical Letters | 2011年 / 22卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Corrole; Manganese; DNA; Oxidative cleavage;
D O I：
暂无
中图分类号：
Q523 [脱氧核糖核酸（DNA）];
学科分类号：
071010 ; 081704 ;
摘要：
The DNA nuclease-like activity of a water soluble manganese corrole 5,10,15-tris(N-methyl-4-pyridyl)- corrolatomanganese (Ⅲ)(Mn~ⅢTMPyC) has been investigated.Mn~ⅢTMPyC may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra,viscosity measurements and CD spectra.Mn~ⅢTMPyC exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide.
引用
收藏
页码：101 / 104
页数：4
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