Implication of EMT Induced by TGF-β1 in Pancreatic Cancer

被引：0

作者：

殷涛

王春友

刘涛

赵刚

周峰

机构：

[1] Wuhan 430022 China

[2] Pancreatic Center Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

[3] Pancreatic Center Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology

来源：

华中科技大学学报(医学英德文版) | 2006年 / 06期

关键词：

pancreatic cancer; TGF-β1; EMT;

D O I：

暂无

中图分类号：

R735.9 [胰腺肿瘤];

学科分类号：

100214 ;

摘要：

This study examined the implication of EMT induced by TGF-β1 in pancreatic cancer invasion. TGF-β1 expression was determined in 29 cases of human pancreatic carcinoma (PC) by immunohistochemistry and the results were compared with those of pathological examination. Moreover, the effects of TGF-β1 on the phenotype and invasion of pancreatic cancer cell line Panc-1 were also investigated. TGF-β1 was detected in 12 cases (41.4 %) of PC. Significant correlation was found between the expression of TGF-β1 and lymph node involvement (P=0.047) and the depth of invasion (P=0.035). TGF-β1 obviously promoted EMT of Panc-1 cell lines and their invasion ability was substantially enhanced. TGF-β1 may promote the malignancy of pancreatic cancer by triggering EMT.

引用

页码：700 / 702

页数：3