Synthesis, Crystal Structure and Biological Activity of a New 4,5-Diaryl-1H-imidazole Derivative

被引：1

作者：

蔡志强 ^{[1
]}

马维英 ^{[1
]}

刘举 ^{[2
]}

胡志泉 ^{[1
]}

侯玲 ^{[1
]}

王建雅 ^{[1
]}

机构：

[1] School of Petrochemical Engineering, Shenyang University of Technology

[2] College of Pharmacy, Liaoning University

来源：

结构化学 | 2014年 / 33卷 / 09期

关键词：

4; 5-diaryl-1H-imidazole; anti-cancer activity; synthesis; crystal structure;

D O I：

10.14102/j.cnki.0254-5861.2014.09.040

中图分类号：

O626.23 [间二氮茂（咪唑）及其衍生物];

学科分类号：

070303 ; 081704 ;

摘要：

A new 4,5-diaryl-1H-imidazole was synthesized and characterized by 1H NMR, ESI-MS, elemental analysis and FT-IR. The crystal structure of the title compound(C19H16Cl2N2O2, Mr = 375.24) has been determined by single-crystal X-ray diffraction. Crystal parameters: monoclinic system, space group P21/n, a = 14.349(3), b = 8.7918(18), c = 15.352(3) , β = 108.56(3)°, V = 1836.1(6) 3, Z = 4, F(000) = 776, Dc = 1.357 g/cm3, μ = 0.368 mm-1, the final R = 0.0502 and wR = 0.1066 for 2324 observed reflections with I > 2σ(I). A total of 16117 reflections were collected, of which 3615 were independent(Rint = 0.0595). The preliminary bioassay suggested that the title compound exhibits distinct effective inhibition on the proliferation of cancer cell lines.

引用

页码：1383 / 1387

页数：5