Bone Remodeling and Energy Metabolism:New Perspectives

被引：0

作者：

Francisco JAde Paula ^{[1
]}

Clifford JRosen ^{[2
]}

机构：

[1] Department of Internal Medicine,School of Medicine of Ribeiro Preto,University of So Paulo,Brazil

[2] Center for Clinical and Translational Research,Maine Medical Center Research Institute,USA

来源：

Bone Research | 2013年 / 1卷 / 01期

关键词：

bone; adipose tissue; mineral metabolism; energy metabolism; leptin; osteocalcin;

D O I：

暂无

中图分类号：

R68 [骨科学（运动系疾病、矫形外科学）];

学科分类号：

1002 ; 100210 ;

摘要：

Bone mineral,adipose tissue and energy metabolism are interconnected by a complex and multilevel series of networks.Calcium and phosphorus are utilized for insulin secretion and synthesis of high energy compounds.Adipose tissue store lipids and cholecalciferol,which,in turn,can influence calcium balance and energy expenditure.Hormones long-thought to solely modulate energy and mineral homeostasis may influence adipocytic function.Osteoblasts are a target of insulin action in bone.Moreover,endocrine mediators,such as osteocalcin,are synthesized in the skeleton but regulate carbohydrate disposal and insulin secretion.Finally,osteoblasts and adipocytes originate from the same mesenchymal progenitor.The mutual crosstalk between osteoblasts and adipocytes within the bone marrow microenvironment plays a crucial role in bone remodeling.In the present review we provide an overview of the reciprocal control between bone and energy metabolism and its clinical implications.

引用

页码：72 / 84

页数：13

共 53 条

[1]

Parathyroid Hormone and Insulin Resistance in Distinct Phenotypes of Severe Obesity: A Cross-Sectional Analysis in Middle-Aged Men and Premenopausal Women[J] . Alfonso Bellia,Giorgia Marinoni,Monica D?Adamo,Valeria Guglielmi,Mauro Lombardo,Giulia Donadel,Paolo Gentileschi,Davide Lauro,Massimo Federici,Renato Lauro,Paolo Sbraccia.The Journal of Clinical Endocrinology ＆ Metabolism . 2012 (12)

[2] Perilipin 2 Improves Insulin Sensitivity in Skeletal Muscle Despite Elevated Intramuscular Lipid Levels [J].

Bosma, Madeleen ;

Hesselink, Matthijs K. C. ;

Sparks, Lauren M. ;

Timmers, Silvie ;

Ferraz, Maria Joao ;

Mattijssen, Frits ;

van Beurden, Denis ;

Schaart, Gert ;

de Baets, Marc H. ;

Verheyen, Fons K. ;

Kersten, Sander ;

Schrauwen, Patrick .

DIABETES, 2012, 61 (11) :2679-2690

[3]

Performance of a multi‐marker Diabetes Risk Score in the Insulin Resistance Atherosclerosis Study （IRAS）, a multi‐ethnic US cohort[J] . Michael W. Rowe,Richard N. Bergman,Lynne E. Wagenknecht,Janice A. Kolberg.Diabetes Metab Res Rev . 2012 (6)

[4]

New insights into osteoporosis: the bone–fat connection[J] . M. Kawai,F. J. A. de Paula,C. J. Rosen.Journal of Internal Medicine . 2012 (4)

[5]

Bone, microenvironment and hematopoiesis[J] . Yi Shen,Susan K. Nilsson.Current Opinion in Hematology . 2012 (4)

[6]

Intramyocellular Lipid Is Associated with Visceral Adiposity, Markers of Insulin Resistance, and Cardiovascular Risk in Prepubertal Children: The EPOCH Study[J] . David E. Brumbaugh,Tessa L. Crume,Kristen Nadeau,Ann Scherzinger,Dana Dabelea.The Journal of Clinical Endocrinology ＆ Metabolism . 2012 (7)

[7] Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells [J].

Velasco, Myrian ;

Larque, Carlos ;

Gutierrez-Reyes, Gabriela ;

Arredondo, Reynaldo ;

Sanchez-Soto, Carmen ;

Hiriart, Marcia .

ISLETS, 2012, 4 (04) :302-311

[8]

FGF23/Klotho axis: Phosphorus, mineral metabolism and beyond[J] . Javier Donate-Correa,Mercedes Muros-de-Fuentes,Carmen Mora-Fernández,Juan F. Navarro-González.Cytokine and Growth Factor Reviews . 2012 (1-2)

[9]

Serum Leptin, Parathyroid Hormone, 1,25-Dihydroxyvitamin D, Fibroblast Growth Factor 23, Bone Alkaline Phosphatase, and Sclerostin Relationships in Obesity[J] . Elizabeth Grethen,Kathleen M. Hill,RoseMarie Jones,Brenda M. Cacucci,Christine E. Gupta,Anthony Acton,Robert V. Considine,Munro Peacock.The Journal of Clinical Endocrinology ＆ Metabolism . 2012 (5)

[10]

Neridronate improves bone mineral density and reduces back pain in β‐thalassaemia patients with osteoporosis: results from a phase 2, randomized, parallel‐arm, open‐label study[J] . Gian Luca Forni,Silverio Perrotta,Andrea Giusti,Giovanni Quarta,Lorella Pitrolo,Maria Domenica Cappellini,Domenico Giuseppe D’Ascola,Caterina Borgna Pignatti,Paolo Rigano,Aldo Filosa,Giovanni Iolascon,Bruno Nobili,Marina Baldini,Alessandra Rosa,Valeria Pinto,Ernesto Palummeri.Br J Haematol . 2012 (2)

← 1 2 3 4 5 6 →