Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer

被引：0

作者：

Jennifer L.Horton

Elena B.Samoilova

Thomas A.Judge

Laurence A.Turka

James M.Wilson

机构：

[1] Department of Molecular and Cellular Engineering

[2] Department of Medicine

[3] University of Pennsylvania School of Medicine

[4] Philadelphia

[5] PA

[6] University of pennsylvania School of Medicine

[7] PA

来源：

实验血液学杂志 | 1997年 / 03期

关键词：

Apo-1/Fas; ligand gene transfer; Amelioration of collagen-induced arthritis by CD95; gene;

D O I：

暂无

中图分类号：

R593.22 [类风湿性关节炎];

学科分类号：

摘要：

<正> Both rheumatoid arthritis and animal models ofautoimmune arthritis are characterized by hyper-activation of synovial cells and hyperplasia of the synovialmembrane. The activated synovial cells produceinflammatory cytokines and degradative enzymes whichlead to destruction of cartilage and bones. Effectivetreatment of arthritis may require elimination of most orall activated synovial cells. The death factor Fas/Apo-1

引用

页码：322 / 322

页数：1