NKT细胞和HIV感染

被引：1
|
作者：
黄孝军 [1 ,2 ]
侯炜 [1 ]
机构：
[1] 武汉大学医学病毒学研究所/病毒学国家重点实验室
[2] 湖北民族学院
来源：
武汉大学学报(医学版) | 2009年 / 30卷 / 04期
关键词：
NKT细胞; HIV-1感染; 细胞因子;
D O I：
10.14188/j.1671-8852.2009.04.006
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
NKT细胞是一群表达半不变量T细胞受体(TCR)的淋巴细胞亚群,它识别由非多态性MHC-Ⅰ类分子CD1d呈递的糖脂。NKT细胞有免疫调节功能,抵抗自身抗原和病原体。最近研究发现,NKT细胞是HIV-1感染的靶细胞之一,且在HIV感染者体内选择性减少。本文着重讨论上述发现的机制、后果以及HIV-1感染治疗前景。
引用
收藏
页码：556 / 560
页数：5
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