CHEMISTRY OF 1,2,4—TRIAZINES XIX THE ANOMALOUS SUBSTITUTED BENZENE SULFONATION AND PROPERTIES OF NUCLEOPHILIC ATTACK ON 6-CARBON OF 3-METHYLTHIO-5-HYDROXY-1,2,4-TRIAZINE

被引：0

作者：

Mei HAN Xu Ling SHI Zhen Jun YANG Meng Shen CAI Tie Ming CHENG School of Pharmaceutical Sciences

机构：

来源：

ChineseChemicalLetters | 1993年 / 09期

基金：

中国国家自然科学基金;

关键词：

NaOH; CHEMISTRY OF 1,2,4; TRIAZINES XIX THE ANOMALOUS SUBSTITUTED BENZENE SULFONATION AND PROPERTIES OF NUCLEOPHILIC ATTACK ON 6-CARBON OF 3-METHYLTHIO-5-HYDROXY-1,2,4-TRIAZINE;

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摘要：

3-Methylthio-5-hydroxy-1,2,4-triazine（1c）reacted withsubstituted benzenesulfonyl chloride to give 3-methylthio-5-oxy-1,2,4-triazin-6-ylpyridinium betaine（4）in anhydrous pyridine.But when NaOH/H;O/CH;COCH;orNaOH/CH;OH were used as reactant and solvent,3-methylthio-4-substitutedbenzenesulfonyl-5-oxo-6-hydroxy-1,4,5,6-tetrahydro-1,2,4-triazine（6）or1-tosyl-3-methylthio-5-oxo-6-methyloxy-1,4,5,6-tetrahydro-1,2,4-triazine（7）wasobtained respectively.The above reactions show anomalous properties of nucleophilicattack on 6-carbon in 1,2,4-triazine ring.

引用

页码：771 / 774

页数：4