Regioselective synthesis and initial evaluation of a folate receptor targeted rhaponticin prodrug

被引：0
|
作者：
Xu Hua Liang~a
机构：
来源：
Chinese Chemical Letters | 2012年 / 23卷 / 10期
关键词：
Rhaponticin(RHA); Targeted therapeutics; Folate; Prodrug; Anticancer;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To improve the therapeutic effect of rhaponticin(RHA),a folate receptor(FR) targeted RHA prodrug was designed and regioselectively synthesized by utilizing a hydrophilic peptide spacer linked to folic acid(FA) via a releasable disulfide linker.A series of biological evaluation was investigated in vitro and in vivo.The positive results of biological investigations warrant further preclinical study before this novel targeted chemotherapeutic is considered for clinical investigation.
引用
收藏
页码：1133 / 1136
页数：4
相关论文
共 50 条
  • [21] Antifolates targeted specifically to the folate receptor
    Jackman, AL
    Theti, DS
    Gibbs, DD
    ADVANCED DRUG DELIVERY REVIEWS, 2004, 56 (08) : 1111 - 1125
  • [22] The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
    Wang, Li
    Zhou, Yubai
    Wu, Xuedan
    Ma, Xinrui
    Li, Bing
    Ding, Ransheng
    Stashko, Michael A.
    Wu, Zhanhong
    Wang, Xiaodong
    Li, Zibo
    MOLECULES, 2022, 27 (05):
  • [23] Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications
    Hulin-Curtis, Sarah L.
    Davies, James A.
    Nestic, Davor
    Bates, Emily A.
    Baker, Alexander T.
    Cunliffe, Tabitha G.
    Majhen, Dragomira
    Chester, John D.
    Parker, Alan L.
    CANCER GENE THERAPY, 2020, 27 (10-11) : 785 - 798
  • [24] Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications
    Sarah L. Hulin-Curtis
    James A. Davies
    Davor Nestić
    Emily A. Bates
    Alexander T. Baker
    Tabitha G. Cunliffe
    Dragomira Majhen
    John D. Chester
    Alan L. Parker
    Cancer Gene Therapy, 2020, 27 : 785 - 798
  • [25] Synthesis and biological evaluation of folate receptor-targeted boronated PAMAM dendrimers as potential agents for neutron capture therapy
    Shukla, S
    Wu, G
    Chatterjee, M
    Yang, WL
    Sekido, M
    Diop, LA
    Müller, R
    Sudimack, JJ
    Lee, RJ
    Barth, RF
    Tjarks, W
    BIOCONJUGATE CHEMISTRY, 2003, 14 (01) : 158 - 167
  • [26] Synthesis and Evaluation of a Novel Lipophilic Folate Receptor Targeting Ligand
    Liu, Ying
    Xu, Songlin
    Teng, Lesheng
    Yung, Bryant
    Zhu, Jing
    Ding, Hong
    Lee, Robert J.
    ANTICANCER RESEARCH, 2011, 31 (05) : 1521 - 1525
  • [27] Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug
    Lu, JY
    Lowe, DA
    Kennedy, MD
    Low, PS
    JOURNAL OF DRUG TARGETING, 1999, 7 (01) : 43 - 53
  • [28] Folate receptor-targeted silica nanoparticles
    Stone, John W.
    Crowe, James E., Jr.
    NANOMEDICINE, 2011, 6 (01) : 16 - 16
  • [29] Targeted drug delivery via the folate receptor
    Sudimack, J
    Lee, RJ
    ADVANCED DRUG DELIVERY REVIEWS, 2000, 41 (02) : 147 - 162
  • [30] Folate receptor-targeted ultrasonic PFOB nanoparticles: Synthesis, characterization and application in tumor-targeted imaging
    Li, Keshi
    Liu, Yahui
    Zhang, Shengmin
    Xu, Youfeng
    Jiang, Jianshuai
    Yin, Fengying
    Hu, Yue
    Han, Baosan
    Ge, Shuxiong
    Zhang, Li
    Wang, Yong
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017, 39 (06) : 1505 - 1515
12345