Regioselective synthesis and initial evaluation of a folate receptor targeted rhaponticin prodrug

被引：0
|
作者：
Xu Hua Liang~a
机构：
来源：
Chinese Chemical Letters | 2012年 / 23卷 / 10期
关键词：
Rhaponticin(RHA); Targeted therapeutics; Folate; Prodrug; Anticancer;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
To improve the therapeutic effect of rhaponticin(RHA),a folate receptor(FR) targeted RHA prodrug was designed and regioselectively synthesized by utilizing a hydrophilic peptide spacer linked to folic acid(FA) via a releasable disulfide linker.A series of biological evaluation was investigated in vitro and in vivo.The positive results of biological investigations warrant further preclinical study before this novel targeted chemotherapeutic is considered for clinical investigation.
引用
收藏
页码：1133 / 1136
页数：4
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