冠心病相关循环miRNA

被引：3

作者：

张月娟 ^{[1
]}

唐文岘 ^{[2
]}

袁肇凯 ^{[1
]}

机构：

[1] 湖南中医药大学医学院

[2] 湖南师范大学生命科学学院

来源：

激光生物学报 | 2013年 / 22卷 / 04期

关键词：

冠心病; 循环miRNA; 生物标志物;

D O I：

暂无

中图分类号：

R541.4 [冠状动脉（粥样）硬化性心脏病（冠心病）];

学科分类号：

1002 ; 100201 ;

摘要：

冠心病诊断中最主要的挑战就是从常规的血液样本中鉴定出可靠的临床生物标志物。循环miRNA是一种可以稳定存在于体液中的小分子RNA,具有较高的组织、疾病特异性及敏感性,具有作为新的冠心病非侵入性生物标志物的潜力。通过综述血液样本(全血、血浆、血清、外周血单核细胞(PBMC)、内皮祖细胞(EPC)及血小板)中冠心病相关循环miRNA,及探讨循环miRNA研究中存在的一些问题,为未来筛选出真正具有临床应用价值的循环miRNA生物标志物奠定基础。

引用

页码：300 / 305

页数：6

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