CATHEPSIN B EXPRESSION AND ITS RELATIONSHIP WITH MICROVESSEL DENSITY AND BIOLOGICAL BEHAVIOUR OF COLORECTAL CARCINOMA

被引：6
作者：
王娅兰
林晓
机构：
来源：
ChineseJournalofCancerResearch | 2002年 / 04期
关键词：
Colorectal carcinoma; Cathepsin B; Invasion; Metastasis; Angiogenesis;
D O I：
暂无
中图分类号：
R735.34 [];
学科分类号：
100214 ;
摘要：
Objective: To investigate cathepsin B(CB) expressionin colorectal carcinoma and its relationship withmicrovessel density (MVD) and biological behavior.Methods: CB and MVD were detected byimmunohistochemistry in 47 cases of colorectal carcinoma. Results: The expression of CB in mucinous colorectalcarcinoma was significantly higher than that inno-mucinous colorectal carcinoma. There was significantdifference (P<0.05). The MVD in group with positive CBwas stronger than that in group with negative CB. There was also significant difference (P<0.05). Conclusion: Theresults suggest that CB expression has correlation withMVD, invasion and metastasis in colorectal carcinoma,especially in mucinous colorectal carcinoma.
引用
收藏
页码：62 / 65
页数：4
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