Syntheses and Bioactivities of 4-Ar-2-oxo-glutaric Acids

被引：0
|
作者：
Schofield Christopher [1 ]
机构：
[1] CRL University of Oxford South Parks Road Oxford OX1 3QY UK
来源：
Chemical Research in Chinese Universities | 2007年 / 03期
关键词：
2-Oxo-glutaric acid; Bioactivity; Inhibitor; Synthesis;
D O I：
暂无
中图分类号：
TQ450.1 [基础理论];
学科分类号：
090403 ;
摘要：
Fourteen novel compounds were synthesized and characterized by using NMR and ESI-MS methods. The bioactivities of the four novel 4-Ar-2-oxo-glutaric acids were studied by using the LC-MS method. The experimental results show that 3-nitrobenzyl-2-oxo-glutaric acid is a mild inhibitor for the hydroxylation reaction catalyzed by PHD2. The decarboxylated peak for 3-fluorobenzyl-2-oxo-glutaric acid was observed by using the negative LC-MS method, indicating that it can be used as a mild cosubstrate to replace 2-OG, but this is possible only in the presence of the prime peptide CODD 19 mer.
引用
收藏
页码：284 / 288
页数：5
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