Syntheses and Bioactivities of 4-Ar-2-oxo-glutaric Acids

被引：0
|
作者：
Schofield Christopher [1 ]
机构：
[1] CRL University of Oxford South Parks Road Oxford OX1 3QY UK
来源：
Chemical Research in Chinese Universities | 2007年 / 03期
关键词：
2-Oxo-glutaric acid; Bioactivity; Inhibitor; Synthesis;
D O I：
暂无
中图分类号：
TQ450.1 [基础理论];
学科分类号：
090403 ;
摘要：
Fourteen novel compounds were synthesized and characterized by using NMR and ESI-MS methods. The bioactivities of the four novel 4-Ar-2-oxo-glutaric acids were studied by using the LC-MS method. The experimental results show that 3-nitrobenzyl-2-oxo-glutaric acid is a mild inhibitor for the hydroxylation reaction catalyzed by PHD2. The decarboxylated peak for 3-fluorobenzyl-2-oxo-glutaric acid was observed by using the negative LC-MS method, indicating that it can be used as a mild cosubstrate to replace 2-OG, but this is possible only in the presence of the prime peptide CODD 19 mer.
引用
收藏
页码：284 / 288
页数：5
相关论文
共 50 条
  • [21] Syntheses, Crystal Structures and Biological Activities of the 2-Oxo-3-phenylpropionic Acid Arylformylhydrazone Dibenzyltin Complexes
    Li Yuan-Xiang
    Yu Hao-Tian
    Zeng Hui-Ting
    Liu Meng-Qin
    Kuang Dai-Zhi
    Tan Yu-Xing
    Jiang Wu-Jiu
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2019, 38 (11) : 1947 - 1955
  • [22] Synthesis of 4-oxo-2-thioxohexahydropyriniidines under ultrasound irradiation
    Li, JT
    Han, JF
    Lin, ZP
    Li, TS
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2004, 24 (06) : 675 - 679
  • [23] Synthesis and antimicrobial activity of substituted 5-cyano-6-oxo-2- styrylnicotinic acids
    Deyanov A.B.
    Konshin M.E.
    Chemistry of Heterocyclic Compounds, 2004, 40 (4) : 452 - 455
  • [24] Syntheses, crystal structures and biological activity of the dialkytin complexes based on 2-oxo-3-phenylpropionic acid salicyloylhydrazone
    Tan, Yuxing
    Zhang, Zhijian
    Tan, Yuhuan
    Kuang, Daizhi
    Yu, Jiangxi
    Zhu, Xiaoming
    Jiang, Wujiu
    JOURNAL OF COORDINATION CHEMISTRY, 2017, 70 (15) : 2606 - 2624
  • [25] Synthesis and antimicrobial evaluation of 1-[4-{4-(2-phenyl-4-oxo-3-quinazolinyl)phenyl}phenyl]-2-phenyl-4-aryl methane-5-oxo-imidazoles
    Undavia, NK
    Trivedi, PB
    Shanishchara, AP
    Trivedi, V
    ASIAN JOURNAL OF CHEMISTRY, 2004, 16 (02) : 1214 - 1216
  • [26] Synthesis and Antibacterial Evaluation of (S,Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids
    Song, Ming-Xia
    Deng, Xian-Qing
    Wei, Zhi-Yu
    Zheng, Chang-Ji
    Wu, Yan
    An, Chang-Shan
    Piao, Hu-Ri
    IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2015, 14 (01): : 89 - 96
  • [27] Synthesis of Novel Indolylbenzothiazepines/ Indolylbenzoxaziepines Substituted 2-Oxo/Thiobarbituric acids as Potential Anticonvulsant Agents
    Archana
    Awasthi, Abha
    Chaudhary, Sakshi
    ORIENTAL JOURNAL OF CHEMISTRY, 2024, 40 (01) : 239 - 246
  • [28] New syntheses on the basis of 4-hydroxy-2H-chromen-2-ones
    Avetisyan, A. A.
    Alvandzhyan, A. G.
    Avetisyan, K. S.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2009, 45 (07) : 1086 - 1090
  • [29] Synthesis and Analgesic Activity of 4-(3-Acyl-2-Aryl-4-Hydroxy-5-Oxo-2,5-Dihydro-1H-Pyrrol-1-yl)Benzoic Acids
    Gein, V. L.
    Chalkov, D. V.
    Romanova, A. V.
    Bobrovskaya, O. V.
    Chaschina, S. V.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2024, 58 (05) : 726 - 729
  • [30] Synthesis of 10-Hydroxy- and 9-Oxo-2e-Decenoic Acids from Oleic Acid
    R. Ya. Kharisov
    O. V. Botsman
    L. P. Botsman
    N. M. Ishmuratova
    G. Yu. Ishmuratov
    G. A. Tolstikov
    Chemistry of Natural Compounds, 2002, 38 : 145 - 148
12345