Synthesis of thiourea derivatives as CCR4 antagonists

被引：0
作者：
Fang Zhao~(a
机构：
来源：
Chinese Chemical Letters | 2009年 / 20卷 / 03期
关键词：
CCR4; antagonists; Thiourea derivatives; Synthesis;
D O I：
暂无
中图分类号：
O621.3 [有机合成化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of thiourea derivatives have been synthesized.Their structures were confirmed by MS and;H NMR.Several compounds showed potent activities as antagonists of CCR4 receptor.
引用
收藏
页码：296 / 299
页数：4
相关论文
共 50 条
  • [1] Synthesis of thiourea derivatives as CCR4 antagonists
    Zhao, Fang
    Xiao, Jun Hai
    Wang, Ying
    Li, Song
    [J]. CHINESE CHEMICAL LETTERS, 2009, 20 (03) : 296 - 299
  • [2] Design, Synthesis and SAR Study of Novel Trisubstituted Pyrimidine Amide Derivatives as CCR4 Antagonists
    Xu, Libao
    Zhang, Yang
    Dai, Wenjie
    Wang, Ying
    Jiang, Dan
    Wang, Lili
    Xiao, Junhai
    Yang, Xiaohong
    Li, Song
    [J]. MOLECULES, 2014, 19 (03) : 3539 - 3551
  • [3] Screening of thiourea derivatives and carbonyl-2-aminothiazole derivatives for potential CCR4 antagonists using capillary zone electrophoresis
    Zhang, Shuyu
    Qi, Hui
    Yakufu, Pazilaiti
    Zhao, Fang
    Ling, Xiaomei
    Xiao, Junhai
    Wang, Ying
    [J]. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 879 (01): : 75 - 82
  • [4] Design and Synthesis of Tri-substituted Chiral Pyrrolidin-2-one Derivatives as CCR4 Antagonists
    Sun, Wei
    Tian, Linjie
    Qi, Hui
    Jiang, Dan
    Wang, Ying
    Li, Song
    Xiao, Junhai
    Yang, Xiaohong
    [J]. CHINESE JOURNAL OF CHEMISTRY, 2013, 31 (09) : 1144 - 1152
  • [5] Design, Synthesis and Biological Activities of a Series of Piperazine Pyrimidine as CCR4 Antagonists
    Gong Hong-Wei
    Qi Hui
    Sun Wei
    Jiang Dan
    Xia Jun-Hai
    Yang Xiao-Hong
    Wang Ying
    Li Song
    [J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2013, 34 (09): : 2131 - 2138
  • [6] Recent progress in the development of antagonists to the chemokine receptors CCR3 and CCR4
    Pease, James Edward
    Horuk, Richard
    [J]. EXPERT OPINION ON DRUG DISCOVERY, 2014, 9 (05) : 467 - 483
  • [7] Racemic and chiral lactams as potent, selective and functionally active CCR4 antagonists
    Newhouse, B
    Allen, S
    Fauber, B
    Anderson, AS
    Eary, CT
    Hansen, JD
    Schiro, J
    Gaudino, JJ
    Laird, E
    Chantry, D
    Eberhardt, C
    Burgess, LE
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (22) : 5537 - 5542
  • [8] Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines
    Yokoyama, Kazuhiro
    Ishikawa, Noriko
    Igarashi, Susumu
    Kawano, Noriyuki
    Hattori, Kazuyuki
    Miyazaki, Takahiro
    Ogino, Shin-ichi
    Matsumoto, Yuzo
    Takeuchi, Makoto
    Ohta, Mitsuaki
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (14) : 7021 - 7032
  • [9] Synthesis of thiourea derivatives on soluble polymeric support
    Yang, GC
    Chen, ZX
    Zhang, ZJ
    [J]. CHINESE JOURNAL OF CHEMISTRY, 2002, 20 (02) : 178 - 182
  • [10] Synthesis of Thiourea Derivatives on Soluble Polymeric Support
    杨桂春
    陈祖兴
    张照军
    [J]. ChineseJournalofChemistry, 2002, (02) : 178 - 182
12345