N-Fluorinated phenyl-N'-pyrimidyl urea derivatives: Synthesis,biological evaluation and 3D-QSAR study

被引：3

作者：

Xia-Li Yue ^{[1
]}

Hu Li ^{[1
]}

Shuang-Shuang Liu ^{[1
]}

Qing-Ye Zhang ^{[1
]}

Jing-Jing Yao ^{[1
]}

Fei-Yan Wang ^{[1
]}

机构：

[1] College of Science, Huazhong Agricultural University

来源：

Chinese Chemical Letters | 2014年 / 07期

基金：

中央高校基本科研业务费专项资金资助; 中国国家自然科学基金;

关键词：

Fluorinated phenyl Pyrimidine QSAR Herbicidal activities;

D O I：

暂无

中图分类号：

TQ254.1 [间（二）氮苯（嘧啶）族]; TQ450.1 [基础理论];

学科分类号：

0817 ; 090403 ;

摘要：

With the increase of herbicide-resistant weeds, novel, more selective and even more potent herbicides to control weeds are needed. In this paper, a series of N-fluorinated phenyl-N0-pyrimidyl urea derivatives were synthesized and screened for their herbicidal activities against Amaranthus retroflexus(AR) and Setaria viridis(SV). Compound 25(N-(3-trifluoromethylphenyl)-N0-(2-amino-4-chloro-6-methylpyrimidyl) urea) exhibited marked herbicidal activity against SV(IC50= 11.67 mg/L) and is more potent than bensulfuron(IC50= 27.45 mg/L), a commercially available herbicide. A statistically significant CoMFA model with high prediction abilities(q2= 0.869, r2= 0.989) was obtained.

引用

页码：1069 / 1072

页数：4

共 3 条

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[2]

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[3]

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