Anti-oxidative role of quercetin derived from Allium cepa on aldehyde oxidase(OX-LDL)and hepatocytes apoptosis in streptozotocininduced diabetic rat

Objective:To study the role of Quercetin in streptozotocin-induced diabetes in rals.Methods:Wistar male rat(n=40) were allocated into three groups,control group(n=10) and Quercetin(QR) group received 15 mg/kg(IP) QR.(n=10),and diabetic group that received 55 mg/kg(IP)streptozotocin(STZ)(n=20) which was subdivided to two groups of 10;STZ group and treatment group.Treatment group received 55mg/kg(IP) STZ plus 15 nig/kg QR,daily lor 4 weeks,respectively:however,the control group just received an equal volume of distilled water dailv(IP).Diabetes was induced by a single(IP) injection of streptozotocin(55 mg/kg).Animal-were kept in standard condition.Twenty-eight days after inducing diabetic,5 mL blood were collected for TAC,MPA and Ox-LDL levels and liver tissues of rat in whole groups were removed then prepared for apoptosis analysis by Tunel method.Results:Apoptotic cells significantly decreased in group that has received 15 mg/kg(IP) Quercetin(P<0.05) in comparison to experimental groups(P<0.05).Conclusions:Since in our study 15 nig/kg(IP) Quercetin have significantly Preventive ellecl on liver cells damages by reducing number of apoptotic cells in Liver,so it seems that using it can be effective for treatment in diabetic rat.