Effect of Different Drugs on End-tidal Carbon Dioxide during Rodent CPR

被引：0

作者：

潘铁成

周淑华

机构：

来源：

JournalofTongjiMedicalUniversity | 1997年 / 04期

关键词：

cardiopulmonary resuscitation; coronary perfusion pressure; end-tidal carbon dioxide; methoxamine; arginine vasopressin; angiotensin-Ⅱ; endothelin-1;

D O I：

暂无

中图分类号：

R965 [实验药理学];

学科分类号：

100602 ; 100706 ;

摘要：

The purpose of this study was to investigate the effect of nonadrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2(ETCO2)during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension- Ⅱ(ANG- Ⅱ), but not by endothelin-1 (ET-1): 2) ETCO2 prior to defibrillation was decreased significantly by a pure a1 adrenergic agents,methoxamine and were increased significantly by non-adrenergic agents, ANG-Ⅱ and ET-1 during rodent CPR;3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-Ⅱ have similar effect on resuscitability during rodent CPR.

引用

页码：244 / 246

页数：3

共 6 条

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