胃癌免疫治疗的进展

被引:6
作者
魏小丽
徐瑞华
机构
[1] 广州,中山大学肿瘤防治中心肿瘤内科中山大学附属肿瘤医院华南肿瘤学国家重点实验室肿瘤医学协同创新中心
关键词
胃肿瘤; 免疫治疗; 免疫检查点;
D O I
暂无
中图分类号
R735.2 [胃肿瘤];
学科分类号
100214 ;
摘要
胃癌是发病率及病死率极高的恶性肿瘤, 化疗及靶向治疗等晚期胃癌的治疗方案非常有限。免疫治疗是抗肿瘤治疗的新生力量。目前研发的药物主要靶向CTLA-4及PD-1 /PD-L通路, Ipilimumab(全人源化的抗CTLA-4抗体)、Pembrolizumab(全人源化的抗PD-1抗体)和Nivolumab(全人源化的抗PD-1抗体)等数种药物已顺利通过临床试验, 并被FDA批准用于黑色素瘤和非小细胞肺癌的治疗。多项临床试验正在验证这些药物在包括晚期胃癌在内的各种晚期实体瘤中的疗效。针对晚期胃癌或胃食管结合部腺癌的临床试验(KEYNOTE-012)发现, 对于PD-L1阳性的晚期胃癌患者, 抗PD-1治疗初步看来是一种安全有效的选择。此外, 多项针对过继性细胞治疗和肿瘤疫苗治疗胃癌的临床试验也正在进行中。本文将对晚期胃癌免疫治疗方面的最新进展进行综述。
引用
收藏
页码:225 / 232
页数:8
相关论文
共 57 条
[1]   The updated incidences and mortalities of major cancers in China, 2011 [J].
Wanqing Chen ;
Rongshou Zheng ;
Hongmei Zeng ;
Siwei Zhang .
Chinese Journal of Cancer, 2015, 34 (11) :502-507
[2]  
TCGA divides gastric cancer into four molecular subtypes:implications for individualized therapeutics[J] Wei Zhang; Chinese Journal of Cancer 2014, 10
[3]   Immune checkpoint inhibitors in clinical trials [J].
Elad Sharon ;
Howard Streicher ;
Priscila Goncalves ;
Helen XChen .
Chinese Journal of Cancer, 2014, 33 (09) :434-444
[4]  
Increasing the frequency of CIK cells adoptive immunotherapy may decrease risk of death in gastric cancer patients[J] Jing-Ting Jiang; Chang-Ping Wu; Lu-Jun Chen; Xiao Zheng; Department of Tumor Biological Treatment; Third Affiliated Hospital of Soochow University; Changzhou 213003; Jiangsu Province; China Yi-Bei Zhu; Jing Sun; Xue-Guang Zhang; Key Laboratory of Stem Cell of Jiangsu Province; Institute of Biotechnology; Key Laboratory of Clinical Immunology of Jiangsu Province; Soochow Universit
[5]  
Programmed cell death protein 1 expression is an independent prognostic factor in gastric cancer after curative resection.[J] Eto Shohei;Yoshikawa Kozo;Nishi Masaaki;Higashijima Jun;Tokunaga Takuya;Nakao Toshihiro;Kashihara Hideya;Takasu Chie;Iwata Takashi;Shimada Mitsuo Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016,
[6]  
Prognostic implications of immunosuppressive protein expression in tumors as well as immune cell infiltration within the tumor microenvironment in gastric cancer.[J] Kim Jin Won;Nam Kyung Han;Ahn Sang-Hoon;Park Do Joong;Kim Hyung-Ho;Kim Se Hyun;Chang Hyun;Lee Jeong-Ok;Kim Yu Jung;Lee Hye Seung;Kim Jee Hyun;Bang Soo-Mee;Lee Jong Seok;Lee Keun-Wook Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 2016,
[7]  
S-1 plus cisplatin versus fluorouracil plus cisplatin in advanced gastric or gastro-esophageal junction adenocarcinoma patients: a pilot study.[J] Li Yu Hong;Qiu Miao Zhen;Xu Jian Ming;Sun Guo Ping;Lu Hui Shan;Liu Yun Peng;Zhong Mei Zuo;Zhang He Long;Yu Shi Ying;Li Wei;Hu Xiao Hua;Wang Jie Jun;Cheng Ying;Zhou Jun Tian;Guo Zeng Qing;Guan Zhon Gzhen;Xu Rui Hua Oncotarget 2015,
[8]  
Combining immunotherapy and anticancer agents: the right path to achieve cancer cure?[J] L. Apetoh;S. Ladoire;G. Coukos;F. Ghiringhelli Annals of Oncology 2015,
[9]  
Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma.[J] Larkin James;Hodi F Stephen;Wolchok Jedd D The New England journal of medicine 2015,
[10]  
EBV-positive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic immune environment[J] Alina Nicolae;Stefania Pittaluga;Shahed Abdullah;Seth M. Steinberg;Thu Anh Pham;Theresa Davies-Hill;Liqiang Xi;Mark Raffeld;Elaine S. Jaffe Blood 2015,