Synthesis, Crystal Structure and Antitumor Activity of 3,3-(1,4-Phenylene)-bisfuro[3,2-d]pyrimidin-4(3H)-ones

被引：0

作者：

黄生田 ^{[1
]}

胡扬根 ^{[2
]}

宋新建 ^{[1
]}

机构：

[1] College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering

[2] College of Pharmacy and Institute of Medicinal Chemistry, Hubei University of Medicine

来源：

ChineseJournalofStructuralChemistry | 2019年 / 38卷 / 06期

关键词：

furo[3,2-d]pyrimidinone; synthesis; crystal structure; antitumor activity;

D O I：

10.14102/j.cnki.0254-5861.2011-2309

中图分类号：

TQ463 [有机化合物药物的生产];

学科分类号：

1007 ;

摘要：

3,3-（1,4-Phenylene）-bis(polysubstituted furo[3,2-d]pyrimidin-4（3 H）-ones 3 were synthesized from the starting material of functionalized iminophosphorane 1 by aza-Wittig reaction. All of the title compounds were characterized by 1H NMR, MS and elemental analysis. Meanwhile, the single crystal of compound 3 c, C46H68N6O10, was also obtained and determined by X-ray crystallography. Crystal data: triclinic, space group P1, a = 9.0017（3）, b = 10.5908（4）, c = 14.0116（5） ?, α = 108.582（2）°, β = 94.296（1）°, γ = 105.059（2）°, V = 1204.40（7） ?3, Z = 1, F（000） = 466, Dc = 1.193 g/cm3, μ = 0.084 mm-1, R = 0.0998 and wR = 0.2146 for 4213 independent reflections（Rint = 0.0689） and 2796 observed ones(I > 2σ（I）). The in vitro antitumor activities of compounds 3 a～3 c were preliminarily evaluated by the standard MTT assay.

引用

页码：918 / 922

页数：5

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