LSP1基因rs3817198 T>C多态性与乳腺癌易感性的meta分析

被引：0
|
作者：
牛明
张显玉
庞达
机构：
[1] 哈尔滨医科大学附属第三医院乳腺外科
来源：
哈尔滨医科大学学报 | 2015年 / 49卷 / 03期
关键词：
LSP rs3817198 T>C; 乳腺癌; meta分析;
D O I：
暂无
中图分类号：
R737.9 [乳腺肿瘤];
学科分类号：
摘要：
目的探讨淋巴细胞特异性蛋白1(lymphocyte-specific protein 1,LSP1)基因rs3817198 T>C多态性与乳腺癌易感性的关系。方法检索Pubmed,Embase和Web of Science数据库,对提取的12个研究结果进行Meta分析。结果 Meta分析结果表明LSP1 rs3817198基因多态性与乳腺癌风险相关(OR=1.07,95%CI 1.05～1.10,P=5.38×10-11)。在所有模型(包括共显性模型、显性模型和隐形模型)中排出GWAS研究后两者也存在相关性。种族和遗传亚组分层分析表明欧洲人群组(OR=1.10;95%CI 1.06～1.14;P=4.19×10-7)和遗传型乳腺癌人群(OR=1.07,95%CI 1.05-1.10,P=1.27×10-8)该位点多态性增加癌症风险。但非洲人群组、亚洲人群组和散发型乳腺癌人群的P值未达到GWAS显著水平。结论 Meta分析表明LSP1基因rs3817198 T>C多态性可能增加乳腺癌的风险。
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页码：271 / 275
页数：5
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