Novel dihydropyrazole derivatives linked with multi(hetero)aromatic ring:Synthesis and antibacterial activity

被引：0
作者：
Lin Shan BaiaYan WangaXin Hua LiuaHai Liang ZhuabBao An Songc a Key Laboratory of Anhui Educational DepartmentAnhui University of TechnologyMaanshan China b State Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing China c Key Laboratory of Green Pesticide and Agriculture BioengineeringMinistry of EducationGuizhou UniversityGuiyang China [243002 ,210093 ,550025 ]
机构：
来源：
Chinese Chemical Letters | 2009年 / 20卷 / 04期
关键词：
Synthesis; Multi(hetero)aromatic pyrazole; Antibacterial activity;
D O I：
暂无
中图分类号：
O621.2 [有机化合物性质];
学科分类号：
070303 ; 081704 ;
摘要：
<正>Eight novel heterocycle-substituted dihydropyrazole derivatives were synthesized and characterized by ESI-MS,1H NMR and 13C NMR.All of the compounds have been screened for their antibacterial potential in vitro against Bacillus subtilis, Staphylococcus aureus,Escherichia coli and Pseudomonas aeruginosa.The results show that compounds 9b,9g and 9h displayed significant activity with MIC values in the range of 0.39-1.562μg/mL against B.subtilis.
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页码：427 / 430
页数：4
相关论文
共 12 条
[1]  
A.A.Bekhita,T.Abdel-Aziem. Bioorg.Med.Chem . 2004
[2]  
Synthesis, Characterization and in vitro anti-invasive activity screening of polyphenolic and heterocyclic compounds. Parmar,VS,Sharma,NK,Husain,M,Watterson,AC,Kumar,J,Samuelson,LA,Cholli,AL,Prasad,AK,Kumar,A,Malhotra,S,Kumar,N,Jha,A,Singh,A,Singh,I,Himanshu,Vats,A,Shakil,NA,Trikha,S,Mukherjee,S,Sharma,SK,Singh,SK,Kumar,A,Jha,HN,Olsen,CE,Stove,CP,Brackef,ME,Mareelf,MM. Bioorganic and Medicinal Chemistry . 2003
[3]  
Synthesis and bioactivity of fluorine containing isoxazolylamino andphosphonate group. Song Baoan,Yang Song,Hong Yanping,et al. Journal of Fluorine Chemistry . 2005
[4]  
Synthesis char- acterization andantibacterial activity of new 3, 5-diaryl pyr- azole oxime ester derivatives. Liu X H,Song B A,Zhu H L,Zuo R B. Chinese Journal of Chemistry . 2008
[5]  
Novel benzofuran and benzothiophene biphanyls as inhibitor of protein tyrosine phosphatase 1B with antihyperglycemic properties. Malamas M S,Sredy J,Moxham C,et al. Journal of Medicinal Chemistry . 2000
[6]  
Synthesis,structure and antibacterial activity of novel1-(5-substituted-3-substituted-4,5-dihydropyrazol-1-yl)ethanone oxi me ester derivatives. Liu X H,Cui P,Song B A,Bhadury P S,Zhu H L,Wang S F. Bioorganic and Medicinal Chemistry Letters . 2008
[7]  
Synthesis and Antibacterial Activity of a Novel Series of Potent DNA Gyrase Inhibitors.Pyrazole Derivatives. TANITAME A,OYAMADA Y,OFUJI K,et al. Journal of Medicinal Chemistry . 2004
[8]  
Design, synthesis, and structure-activity relationship studies of ATP analogues as DNA gyrase inhibitors. Lubbers T,Angehrn P,Gmunder H,et al. Bioorganic and Medicinal Chemistry . 2000
[9]  
Design,synthesis and structure-activity relationship stud-ies of novel indazole analogues as DNA gyrase inhibitorswith Gram-positive antibacterial activity. Akihilko Tanitame,Yoshihiro Oyamada,Keiko Ofuji. Bioorganic&Medicinal Chemistry Letters . 2004
[10]  
X.H.Liu,L.P.Zhi,et al. Chem.Res.Chin.Univ . 2008
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