BCL11基因与恶性肿瘤的关系

被引：2
|
作者：
门万夫
李文雅
钟欣文
李玉
机构：
[1] 中国医科大学附属第一医院胸外科一病房
来源：
现代肿瘤医学 | 2016年 / 24卷 / 08期
关键词：
BCL11A; BAL11B; 基因; 恶性肿瘤;
D O I：
暂无
中图分类号：
R730.2 [肿瘤病理学、病因学];
学科分类号：
摘要：
B细胞淋巴瘤/白血病(B-cell lymphoma/leukemia,BCL)家族蛋白在细胞的增殖和抗凋亡等方面起重要作用。BCL11基因是BCL家族的成员之一,分为BCL11A和BCL11B基因。其中BCL11A基因是一种原癌基因,而BCL11B被认为是一种抑癌基因,近年来人们逐渐认识到了它们的结构与特点。越来越多的研究发现,它们不仅与血液系统淋巴细胞肿瘤的关系密切,还与很多其它系统的恶性肿瘤有着一定关系。本文主要介绍BCL11基因特点、功能,并结合最新的资料将其与人类各系统恶性肿瘤关系的研究做一综述。
引用
收藏
页码：1311 / 1315
页数：5
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