Enhancing endothelial progenitor cell for clinical use

被引：0

作者：

Lei Ye ^{[1
]}

Kian-Keong Poh ^{[2
,3
]}

机构：

[1] National Heart Research Institute Singapore,National Heart Centre Singapore

[2] Department of Medicine,Yong Loo Lin School of Medicine,National University of Singapore

[3] Department of Cardiology,National University Heart Center,National University Health System

来源：

World Journal of Stem Cells | 2015年 / 7卷 / 06期

关键词：

Endothelial progenitor cells; Cell therapy; Enhancing function and number; CD34; Clinical trials;

D O I：

暂无

中图分类号：

R54 [心脏、血管（循环系）疾病];

学科分类号：

1002 ; 100201 ;

摘要：

Circulating endothelial progenitor cells(EPCs) have been demonstrated to correlate negatively with vascularendothelial dysfunction and cardiovascular risk factors. However, translation of basic research into the clinical practice has been limited by the lack of unambiguous and consistent definitions of EPCs and reduced EPC cell number and function in subjects requiring them for clinical use. This article critically reviews the definition of EPCs based on commonly used protocols, their value as a biomarker of cardiovascular risk factor in subjects with cardiovascular disease, and strategies to enhance EPCs for treatment of ischemic diseases.

引用

页码：894 / 898

页数：5

共 21 条

[1] Endothelial progenitor cells in cardiovascular diseases [J].

Poay Sian Sabrina Lee ;

Kian Keong Poh .

World Journal of Stem Cells, 2014, (03) :355-366

[2] Atorvastatin treatment improves endothelial function through endothelial progenitor cells mobilization in ischemic heart failure patients [J].

Oikonomou, Evangelos ;

Siasos, Gerasimos ;

Zaromitidou, Marina ;

Hatzis, George ;

Mourouzis, Konstantinos ;

Chrysohoou, Christine ;

Zisimos, Konstantinos ;

Mazaris, Savvas ;

Tourikis, Panagiotis ;

Athanasiou, Dimitris ;

Stefanadis, Christodoulos ;

Papavassiliou, Athanasios G. ;

Tousoulis, Dimitris .

ATHEROSCLEROSIS, 2015, 238 (02) :159-164

[3]

Thymosin β4 Increases the Potency of Transplanted Mesenchymal Stem Cells for Myocardial Repair[J] . Lei Ye,Pengyuan Zhang,Sue Duval,Liping Su,Qiang Xiong,Jianyi Zhang.Circulation . 2013 (11 s)

[4]

Ephrin-B2–Activated Peripheral Blood Mononuclear Cells From Diabetic Patients Restore Diabetes-Induced Impairment of Postischemic Neovascularization[J] . Dong Broquères-You,Carole Leré-Déan,Tatiana Merkulova-Rainon,Chris S. Mantsounga,David Allanic,Patricia Hainaud,Jean-Olivier Contrères,Yu Wang,José Vilar,Marie Virally,Jean-Jacques Mourad,Pierre-Jean Guillausseau,Jean-Sébastien Silvestre,Bernard I. Lévy.Diabetes . 2012 (10)

[5]

Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse[J] . Jian Zhu,Li-Ping Su,Lei Ye,Kok-Onn Lee,Jian-Hua Ma.Diabetes Research and Clinical Practice . 2011 (1)

[6]

Circulating microparticles and endothelial progenitor cells in atherosclerosis: pharmacological effects of irbesartan[J] . A.GEORGESCU,N.ALEXANDRU,E.ANDREI,I.TITORENCU,E.DRAGAN,C.TARZIU,S.GHIORGHE,E.BADILA,D.BARTOS,D.POPOV.Journal of Thrombosis and Haemostasis . 2012 (4)

[7]

Intramyocardial, Autologous CD34+ Cell Therapy for Refractory Angina[J] . Douglas W. Losordo,Timothy D. Henry,Charles Davidson,Joon Sup Lee,Marco A. Costa,Theodore Bass,Farrell Mendelsohn,F. David Fortuin,Carl J. Pepine,Jay H. Traverse,David Amrani,Bruce M. Ewenstein,Norbert Riedel,Kenneth Story,Kerry Barker,Thomas J. Povsic,Robert A. Harrington,Richard A. Schatz.Circulation Research . 2011 (4)

[8] Sonic Hedgehog-Induced Functional Recovery After Myocardial Infarction Is Enhanced by AMD3100-Mediated Progenitor-Cell Mobilization [J].

Roncalli, Jerome ;

Renault, Marie-Ange ;

Tongers, Joern ;

Misener, Sol ;

Thorne, Tina ;

Kamide, Christine ;

Jujo, Kentaro ;

Tanaka, Toshikazu ;

Ii, Masaaki ;

Klyachko, Ekaterina ;

Losordo, Douglas W. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2011, 57 (24) :2444-2452

[9]

Endothelial Dysfunction, Inflammation, and Apoptosis in Diabetes Mellitus[J] . Inge A. M. van den Oever,Hennie G. Raterman,Mike T. Nurmohamed,Suat Simsek,Oreste Gualillo.Mediators of Inflammation . 2010

[10] Endothelial progenitor cells in neovascularization of infarcted myocardium [J].

Jujo, Kentaro ;

Ii, Masaaki ;

Losordo, Douglas W. .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 45 (04) :530-544

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