R5 to X4 coreceptor switch of human immunodeficiency virus type 1B' and B'/C recombinant subtype isolates in China

被引：0

作者：

GUO Yan-fang MA Li-ying YUAN Lin WANG Shu-hua SUN Jian-ping XU Wei-si Xu Jian-qing XING Hui HONG Kun-xue ZHANG Xiao-yan RUAN Yu-hua ZHANG Yao-xin SHAO Yi-ming State Key Laboratory for Infection Diseases Prevention and Control

机构：

来源：

中华医学杂志(英文版) | 2007年 / 06期

关键词：

HIV-1; B’/C recombinant viruses; subtype B; coreceptor switch;

D O I：

暂无

中图分类号：

R512.91 [获得性免疫缺陷综合征（AIDS艾滋病）];

学科分类号：

100401 ;

摘要：

The chemokine receptors CCR5 and CXCR4 play animportant role as coreceptors for humanimmunodeficiency virus type 1(HIV-1)entring into cells.HIV-1 isolates can be distinguished by the chemokinecoreceptors.Nonsyncytium inducing(NSI),macrophagetropic viruses utilizing CCR5,are called R5 viruses;syncytium inducing(SI)isolates use CXCR4 and knownas X4 viruses.R5 viruses generally are associated withlatent stage of infection and X4 viruses with later,more

引用

页码：522 / 525

页数：4

共 3 条

[1] Evolving patterns of HIV-1 resistance to antiretroviral agents in newly infected individuals [J].

Simon, V ;

Vanderhoeven, J ;

Hurley, A ;

Ramratnam, B ;

Louie, M ;

Dawson, K ;

Parkin, N ;

Boden, D ;

Markowitz, M .

AIDS, 2002, 16 (11) :1511-1519

[2] Quantitative evaluation of HIV-1 coreceptor use in the GHOST(3) cell assay [J].

Vödrös, D ;

Tscherning-Casper, C ;

Navea, L ;

Schols, D ;

De Clercq, E ;

Fenyö, EM .

VIROLOGY, 2001, 291 (01) :1-11

[3]

Neutralization profiles of primary human immunodeficiency virus type 1 isolates in the context of coreceptor usage .2 Cecilia D,KewalRamani VN,O‘Leary J,et al. J Virol . 1998

← 1 →