MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma

被引：22

作者：

Cameron M Smith ^{[1
]}

David I Watson ^{[1
]}

Michael Z Michael ^{[2
]}

Damian J Hussey ^{[1
]}

机构：

[1] Department of Surgery, Flinders University, Room 3D211, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia

[2] Department of Gastroenterology & Hepatology, Flinders University, Bedford Park, South Australia 5042, Australia

来源：

World Journal of Gastroenterology | 2010年 / 16卷 / 05期

关键词：

Barrett’s esophagus; MicroRNA; Esophageal adenocarcinoma; Transdifferentiation; Tumour suppressor;

D O I：

暂无

中图分类号：

R735.1 [食管肿瘤]; R571 [食管疾病];

学科分类号：

1002 ; 100201 ; 100214 ;

摘要：

Barrett’s esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett’s esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellular processes, and the role of miRNAs in disease development is be-coming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett’s esophagus and its progression to cancer.

引用

页码：531 / 537

页数：7

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