Th17细胞与HIV感染的关系

被引：0

作者：

尹慧彬 ^{[1
]}

骆丹 ^{[1
]}

机构：

[1] 南京医科大学第一附属医院皮肤性病科

来源：

国际皮肤性病学杂志 | 2011年 / 02期

关键词：

Th17细胞; HIV; 感染;

D O I：

暂无

中图分类号：

R512.91 [获得性免疫缺陷综合征（AIDS艾滋病）];

学科分类号：

100401 ;

摘要：

来源于初始T细胞的Th17细胞是新发现的一类不同于Th1、Th2的CD4~+T细胞,其分泌IL-17、IL-6、IL-22和肿瘤坏死因子等细胞因子,在介导慢性炎症反应、自身免疫性疾病等方面发挥着重要作用。研究表明,IL-17在HIV感染中发挥着抗感染作用,同时在抗HIV细胞因子调控网络中,IL-17也起着重要作用。在HIV感染早期,Th17细胞在外周血液及胃肠道中大量减少甚至衰竭,但是Th17能否发挥抗病毒功能还需要更深入探究。研究已证明,病毒首先攻击的靶点细胞是CCR5~+CCR6~+Th17。Th17作为HIV新的靶向细胞,有望为艾滋病提供新的治疗策略。

引用

共 32 条

[1] The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells
Ivanov, Ivaylo I.
McKenzie, Brent S.
Zhou, Liang
Tadokoro, Carlos E.
Lepelley, Alice
Lafaille, Juan J.
Cua, Daniel J.
Littman, Dan R.
[J]. CELL, 2006, 126 (06) : 1121 - 1133
[2] New players in cytokine control of HIV infection
Alfano M.
Crotti A.
Vicenzi E.
Poli G.
[J]. Current HIV/AIDS Reports, 2008, 5 (1) : 27 - 32
[3] Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection
Ndhlovu, Lishomwa C.
Chapman, Joan M.
Jha, Aashish R.
Snyder-Cappione, Jennifer E.
Pagan, Moraima
Leal, Fabio E.
Boland, Brigid S.
Norris, Philip J.
Rosenberg, Michael G.
Nixon, Douglas F.
[J]. AIDS, 2008, 22 (08) : 990 - 992
[4] Good for Goose, but Not for Gander: IL-2 Interferes with Th17 Differentiation[J] . Brigitta Stockinger. &nbspImmunity . 2007 (3)
[5] Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties[J] . Casey T. Weaver,Laurie E. Harrington,Paul R. Mangan,Maya Gavrieli,Kenneth M. Murphy. &nbspImmunity . 2006 (6)
[6] Beyond IL-17: new cytokines in the pathogenesis of HIV infection[J] . Mario Clerici. &nbspCurrent Opinion in HIV and AIDS . 2010 (2)
[7] Interleukin-17 family and IL-17 receptors
Moseley, TA
Haudenschild, DR
Rose, L
Reddi, AH
[J]. CYTOKINE & GROWTH FACTOR REVIEWS, 2003, 14 (02) : 155 - 174
[8] HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells
Prendergast, Andrew
Prado, Julia G.
Kang, Yu-Hoi
Chen, Fabian
Riddell, Lynn A.
Luzzi, Graz
Goulder, Philip
Klenerman, Paul
[J]. AIDS, 2010, 24 (04) : 491 - 502
[9] Good for goose,but not for gander:IL-2 interferes with Th17 differentiation. Stockinger B. Immunity . 2007
[10] Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Cua DJ,Sherlock J,Chen Y,et al. Nature . 2003

← 1 2 3 4 →