Expression of differential nitric oxide synthase isoforms in human gastric mucosa infected with Helicobacter pylori

被引：0
作者：
屠振兴
龚燕芳
丁华
许国铭
李兆申
满晓华
机构：
[1] Department of Gastroenterology
[2] Changhai Hospital
[3] Second Military Medical University
[4] Shanghai
[5] China
来源：
Journal of Medical Colleges of PLA | 2003年 / 05期
关键词：
H; pylori; nitric oxide synthase; immunohistochemistry;
D O I：
暂无
中图分类号：
R573 [胃疾病];
学科分类号：
1002 ; 100201 ;
摘要：
<正> Objective: To study the relationship between nitric oxide synthase ( NOS) expression in human gastric mu-cosa and Helicobacter pylori (H. pylori) infection. Methods: Gastric mucosa samples were obtained from antrum of 33 patients received gastroendoscopy. H. pylori infection was confirmed by Giems staining and bacteria culture under mi-croaerophilic conditions. Expression of iNOS, eNOS and nitrotyrosine were detected by immunohistochemistry. Results: (1) The positive rate of H. pylori infection was 66. 7% (22/33) . (2) iNOS positive staining in inflammatory cells was detected in 77. 3% (17/22) of samples with H. pylori and 27. 3% (3/11) without H. pylori infection (P < 0.01). (3) eNOS expression in inflammatory cells was found in 77. 3% (17/22) of samples with H. pylori and 18.2% (2/11) without H. pylori infection ( P < 0. 01) . (4) Nitrotyrosine expression in inflammatory cells was observed in 59. 1% ( 13/22) of samples with H. pylori and 54.5%(6/11) without H. pylori infection (P>0.05). (5) Moderate a
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页码：286 / 289
页数：4
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