Insights for hepatitis C virus related hepatocellular carcinoma genetic biomarkers: Early diagnosis and therapeutic intervention

被引：2
作者：
Wafaa M Ezzat [1 ]
Khalda Sayed Amr [2 ]
机构：
[1] Department of Internal Medicine, National Research Center
[2] Department of Medical Molecular Genetics,National Research Center
来源：
World Journal of Hepatology | 2016年 / 30期
关键词：
Hepatitis C virus; Hepatocellular carcinoma; Genetic; Epigenetic; Diagnosis;
D O I：
暂无
中图分类号：
R735.7 [肝肿瘤]; R512.63 [];
学科分类号：
100214 ; 100401 ;
摘要：
The current review explores the role of emerging molecular contributing factors in liver carcinogenesis on top of hepatitis C virus(HCV). Here we will try to discuss the role genetic and epigenetic factors in pathogenesis of hepatocellular carcinoma. Understanding the role of these factors will help in discovering the mystery of liver carcinogenesis on top of chronic HCV infection. Moreover, use of the studied molecular factors will provide the hepatologists with tailored diagnostic promising biomarkers and flatten the way for establishment of emerging molecular treatment based on exploring the molecular subscription of this aggressive liver cancer.
引用
收藏
页码：1251 / 1261
页数：11
相关论文
共 55 条
[1]   The potential role of miRNAs 21 and 199-a in early diagnosis of hepatocellular carcinoma [J].
Amr, Khalda Said ;
Ezzat, Wafaa M. ;
Elhosary, Yasser A. ;
Hegazy, Abdelfattah E. ;
Fahim, Hoda H. ;
Kamel, Refaat R. .
GENE, 2016, 575 (01) :66-70
[2]   An Analysis of Immunoreactive Signatures in Early Stage Hepatocellular Carcinoma [J].
Hong, Yu ;
Long, Jiang ;
Li, Hai ;
Chen, Shuhong ;
Liu, Qiqi ;
Zhang, Bei ;
He, Xiaomin ;
Wang, Yan ;
Li, Hongyi ;
Li, Yimei ;
Zhang, Tao ;
Lu, Chenzhen ;
Yan, Hao ;
Zhang, Minli ;
Li, Qing ;
Cao, Bangwei ;
Bai, Zhigang ;
Wang, Jin ;
Zhang, Zhongtao ;
Zhu, Shengtao ;
Zheng, Jiasheng ;
Ou, Xiaojuan ;
Ma, Hong ;
Jia, Jidong ;
You, Hong ;
Wang, Shengqi ;
Huang, Jian .
EBIOMEDICINE, 2015, 2 (05) :438-446
[3]  
Serum miR-224 Reflects Stage of Hepatocellular Carcinoma and Predicts Survival[J] . Li-ping Zhuang,Zhi-qiang Meng,Mathew Coleman.BioMed Research International . 2015
[4]  
Pathogenesis and prevention of hepatitis C virus-induced hepatocellular carcinoma[J] . Yujin Hoshida,Bryan C. Fuchs,Nabeel Bardeesy,Thomas F. Baumert,Raymond T. Chung.Journal of Hepatology . 2014 (1)
[5]  
Virus associated malignancies: The role of viral hepatitis in hepatocellular carcinoma[J] . Amir Shlomai,Ype P. de Jong,Charles M. Rice.Seminars in Cancer Biology . 2014
[6]  
A case of transfusion related acute lung injury in a thalassemic child[J] . Anupama Agrawal,Deepak Kumar,Tarun Verma,Rakesh Gupta.Medical Journal Armed Forces India . 2014
[7]  
Cancer statistics, 2014[J] . Rebecca Siegel,Jiemin Ma,Zhaohui Zou,Ahmedin Jemal.CA A Cancer Journal for Clinicians . 2014 (1)
[8]  
Tumor markers for hepatocellular carcinoma (Review)[J] . Yan-Jie Zhao,Qiang Ju,Guan-Cheng Li.Molecular and Clinical Oncology . 2013 (4)
[9]   Overexpression of CXCL5 Mediates Neutrophil Infiltration and Indicates Poor Prognosis for Hepatocellular Carcinoma [J].
Zhou, Shao-Lai ;
Dai, Zhi ;
Zhou, Zheng-Jun ;
Wang, Xiao-Ying ;
Yang, Guo-Huan ;
Wang, Zheng ;
Huang, Xiao-Wu ;
Fan, Jia ;
Zhou, Jian .
HEPATOLOGY, 2012, 56 (06) :2242-2254
[10]   Prognostic Significance of Alpha-fetoprotein Status in the Outcome of Hepatocellular Carcinoma after Treatment of Transarterial Chemoembolization [J].
Wang, Yan ;
Chen, Yi ;
Ge, Ningling ;
Zhang, Lan ;
Xie, Xiaoying ;
Zhang, Jubo ;
Chen, Rongxin ;
Wang, Yanhong ;
Zhang, Boheng ;
Xia, Jinglin ;
Gan, Yuhong ;
Ren, Zhenggang ;
Ye, Shenglong .
ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (11) :3540-3546
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