TOR(target of rapamycin)介导的翻译调控

[1] Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. CAFFERKEY R,YOUNG P R,MCLAUGHLIN M M,et al. Molecular and Cellular Biology . 1993

[2] The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. BIONDI R M,KIELOCH A,CURRIE R A,et al. EMBO Journal . 2001

[3] TOR, a central controller of cell growth. SCHMELZLE T,HALL M N. Cell . 2000

[4] A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. HARDING M W,GALAT A,UEHLING D E,et al. Nature . 1989

[5] Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. GINGRAS A C,GYGI S P,RAUGHT B,et al. Genes and Development . 1999

[6] Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four(S/T)P sites detected by phospho-specific antibodies. MOTHE S I,BRUNN G J,MCMAHON L P,et al. Journal of Biological Chemistry . 2000

[7] The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4EBP1 at multiple sites. HERBERT T P,TEE A R,PROUD C G. Journal of Biological Chemistry . 2002

[8] Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. BOHNI R,RIESGO- ESCOVAR J,OLDHAM S,et al. Cell . 1999

[9] Multiple independent inputs are required for activation of the p70 S6 kinase. WENG Q P,ANDRBI K,KOZLOWSKI M T,et al. Molecular and Cellular Biology . 1995

[10] Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling. GAO X,ZHANG Y,ARRAZOLA P,et al. Nature Cell Biology . 2002

[1] Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity. CAFFERKEY R,YOUNG P R,MCLAUGHLIN M M,et al. Molecular and Cellular Biology . 1993

[2] The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. BIONDI R M,KIELOCH A,CURRIE R A,et al. EMBO Journal . 2001

[3] TOR, a central controller of cell growth. SCHMELZLE T,HALL M N. Cell . 2000

[4] A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase. HARDING M W,GALAT A,UEHLING D E,et al. Nature . 1989

[5] Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. GINGRAS A C,GYGI S P,RAUGHT B,et al. Genes and Development . 1999

[6] Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four(S/T)P sites detected by phospho-specific antibodies. MOTHE S I,BRUNN G J,MCMAHON L P,et al. Journal of Biological Chemistry . 2000

[7] The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4EBP1 at multiple sites. HERBERT T P,TEE A R,PROUD C G. Journal of Biological Chemistry . 2002

[8] Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. BOHNI R,RIESGO- ESCOVAR J,OLDHAM S,et al. Cell . 1999

[9] Multiple independent inputs are required for activation of the p70 S6 kinase. WENG Q P,ANDRBI K,KOZLOWSKI M T,et al. Molecular and Cellular Biology . 1995

[10] Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling. GAO X,ZHANG Y,ARRAZOLA P,et al. Nature Cell Biology . 2002