解郁丸对WKY大鼠的抑郁样行为及海马和前额叶皮层BDNF表达的影响

被引：8

作者：

宋苗 ^{[1
]}

刘红梅 ^{[1
]}

李琦 ^{[2
]}

张宇 ^{[1
]}

徐勇 ^{[2
]}

机构：

[1] 山西医科大学基础医学院

[2] 山西医科大学第一医院精神卫生科

来源：

中国病理生理杂志 | 2019年 / 35卷 / 06期

关键词：

解郁丸; 抑郁症; 脑源性神经营养因子; Wistar-Kyoto大鼠;

D O I：

暂无

中图分类号：

R285.5 [中药实验药理];

学科分类号：

1008 ;

摘要：

目的:观察解郁丸对Wistar-Kyoto(WKY)大鼠抑郁样行为及脑源性神经营养因子(BDNF)在海马和前额叶皮层表达的影响,探讨其抗抑郁作用及相关机制。方法:成年雄性WKY大鼠为内源性抑郁动物模型,选取同品系Wistar大鼠作为空白对照组,WKY大鼠随机分为模型组、西酞普兰组和解郁丸组,分别灌胃给药21 d后,用糖水偏好实验及强迫游泳实验观察各组大鼠抑郁行为变化;采用免疫荧光法和Western blot法检测海马及前额叶皮层BDNF表达水平的变化。结果:WKY大鼠表现出明显的抑郁样行为,海马及前额叶皮层的BDNF表达量显著下降,且海马区神经元轴突减少(P<0.01);在药物治疗后,WKY大鼠的抑郁样行为明显减少,BDNF在海马及前额叶皮层中的表达增加,且轴突数目也增加(P<0.01)。结论:解郁丸能有效减少WKY大鼠的抑郁样行为;BDNF是其抗抑郁作用发挥的关键因子。本研究也进一步验证BDNF参与抑郁的发生发展过程。

引用

页码：1124 / 1129

页数：6

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