EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM

被引：0

作者：

李箭

汪钟

机构：

[1] PUMC Student

[2] Institute of Basic Medical Sciences CAMS

[3] Beijing

来源：

Chinese Medical Sciences Journal | 1990年 / 01期

关键词：

nimodipine; platelet aggregation; TXB2; 6-keto-PGF1α; cyclooxygenase;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

<正> The effects of nimodipine on platelet aggregation and arachidonic acid（AA）metabolismwere studied in order to explore its effect on patients with thrombosis or cardiovas-cular disease.The results indicate that nimodipine（50-350μmol/L）significantly inhibitsplatelet aggregation induced by ADP,AA,and ionophore A23187 in a dose dependentmanner.The inhibitory effects induced by ionophore A23187 could be partially antagonizedby calcium（1 mmol/L）.When the substrate was AA and the enzyme was supplied bypig lung microsomes,nimodipine（50-400μmol/L）significantly reduced the generation ofTXB2 and 6-keto-PGF1a in parallel.When the substrate was prostaglandin endoperoxide,however,the levels of TXB2 and 6-keto-PGF1awere not significantly altered in the sameconcentration range.The results suggest that nimodipine is a cyclooxygenase inhibitor,andits ability to inhibit platelet aggregation is related to its calcium blocking effect.

引用

页码：47 / 50

页数：4