Aptamer-based self-assembled supramolecular vesicles for pH-responsive targeted drug delivery

被引：0

作者：

Shuxian Wu ^{[1
]}

Juan Li ^{[1
]}

Hong Liang ^{[1
]}

Liping Wang ^{[1
]}

Xian Chen ^{[1
]}

Guixiao Jin ^{[2
]}

Xiaoping Xu ^{[1
]}

Huang-Hao Yang ^{[1
]}

机构：

[1] Key Laboratory of Analysis and Detection Technology for Food Safety of the Ministry of Education, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University

[2] College of Ecological Environment and Urban Construction, Fujian University of Technology

来源：

Science China(Chemistry) | 2017年 / 05期

基金：

中国国家自然科学基金;

关键词：

aptamer; supramolecular vesicle; pH-responsive; drug delivery;

D O I：

暂无

中图分类号：

TQ460.1 [基础理论];

学科分类号：

1007 ;

摘要：

Supramolecular vesicles have received great attention in biomedical application due to their inherent features, including simple synthesis and tunable amphiphilicity of the building blocks. Despite tremendous research efforts, developing supramolecular vesicles with targeted recognition and controlled release remains a major challenge. Herein, we constructed a novel aptamer-based self-assembled supramolecular vesicle by host-guest complexation of pyrene, viologen lipid, and cucurbit[8]urils for pH-responsive and targeted drug delivery. The proposed supramolecular vesicles are easy to be assembled and offer simple drug loading. Based on confocal fluorescence microscopy and cytotoxicity experiments, the drug-loaded supramolecular vesicles were shown to possess highly efficient internalization and apparent cytotoxic effect on target cancer cells, but not control cells.Furthermore, through simple aptamer or drug substitution, supramolecular vesicles can be applied to a variety of target cell lines and drugs, making it widely applicable. Taking advantage of the easy preparation, good stability, rapid pH response, and cell targeting ability, the aptamer-based self-assembled supramolecular vesicles hold great promise in controlled-release biomedical applications and targeted cancer therapy.

引用

页码：628 / 634

页数：7