One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer

被引:0
作者
Maria Aparecida Mesquita
S(o|^)nia Letícia Silva Lorena
Jazon Romilson Souza Almeida
Ciro Garcia Montes
Fábio Guerrazzi
Luciana T Campos
José Murilo Rubiota Zeitune
机构
[1] Brazil
[2] Faculty of Medical Sciences
[3] Gastroenterology Unit
[4] Gastroenterology Unit Medical Clinic Department
[5] State University of Campinas
关键词
Helicobacter pylori; Ranitidine bismuth citrate; Clarithromycin; Peptic ulcer;
D O I
暂无
中图分类号
R573.1 [溃疡病];
学科分类号
1002 ; 100201 ;
摘要
AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer. METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1)1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment. RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%, respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, and appears to be comparable to the 2-wk regimen in terms of efficacy.x
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收藏
页码:3566 / 3569
页数:4
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