Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis

被引：5

作者：

Li Chun ^{[1
,2
,3
,4
]}

Zhang Yan ^{[1
,5
,6
,4
]}

Song Hui ^{[1
,5
,6
,4
]}

Gao Jie ^{[1
,7
,8
,4
]}

Zhao DongBao ^{[1
,7
,8
,4
]}

Zhu Qi ^{[9
,10
,11
,4
]}

He DongYi ^{[9
,10
,11
,4
]}

Wang Li ^{[1
,12
,13
,14
,4
]}

Li XiangPei ^{[1
,12
,13
,14
,4
]}

Liu XuDong ^{[1
,15
,16
,17
,4
]}

Xiao WeiGuo ^{[1
,15
,16
,17
,4
]}

Wu XinYu ^{[9
,18
,19
,20
,4
]}

Wu HuaXiang ^{[9
,18
,19
,20
,4
]}

Tu Wei ^{[1
,21
,22
,23
,4
]}

Hu ShaoXian ^{[1
,21
,22
,23
,4
]}

Wang Xin ^{[9
,24
,25
,26
,4
]}

Li ZhiJun ^{[9
,24
,25
,26
,4
]}

Lu ZhiMin ^{[1
,27
,28
,29
,4
]}

Da ZhanYun ^{[1
,27
,28
,29
,4
]}

Liang Bo ^{[1
,30
,31
,4
]}

Liu XiaoMin ^{[1
,30
,31
,4
]}

Zhao JinWei ^{[32
,33
,34
,4
]}

Li Ling ^{[32
,33
,34
,4
]}

Han Feng ^{[1
,35
,36
,4
]}

Qi WuFang ^{[1
,35
,36
,4
]}

Wei Wei ^{[1
,37
,38
,4
]}

Ma Xu ^{[1
,39
,40
,41
,4
]}

Li ZhenBin ^{[1
,39
,40
,41
,4
]}

Zheng GuiMin ^{[1
,42
,40
,43
,4
]}

Zhang FengXiao ^{[1
,42
,40
,43
,4
]}

Li Yi ^{[9
,44
,45
,46
,4
]}

Wang YouLian ^{[9
,44
,45
,46
,4
]}

Ling GuangHui ^{[47
,48
,49
,50
,4
]}

Chen JinWei ^{[47
,48
,49
,50
,4
]}

Hou XiaoQiang ^{[1
,51
,52
,53
,4
]}

Zhang Jing ^{[54
,55
,56
,57
,4
]}

Chen QingPing ^{[54
,55
,56
,57
,4
]}

Liu ChangLian ^{[58
,55
,56
,57
,4
]}

Zhang Yan ^{[59
,60
,61
,62
,4
]}

Zeng JiaShun ^{[59
,60
,61
,62
,4
]}

Zou QingHua ^{[9
,63
,64
,4
]}

Fang YongFei ^{[9
,63
,64
,4
]}

Su Yin

Li ZhanGuo ^{[1
,2
,3
,4
]}

机构：

[1] Department of Rheumatology and Immunology

[2] Peking University People’s Hospital

[3] Beijing

[4] China

[5] Beijing Jishuitan Hospital

[6] Changhai Hospital

[7] Shanghai

[8] Department of Rheumatology

[9] Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine

[10] Anhui Provincial Hospital

[11] Hefei

[12] Anhui

[13] The First Hospital of China Medical University

[14] Shenyang

[15] Liaoning

[16] The Second Affiliated Hospital of Zhejiang University School of Medicine

[17] Hangzhou

[18] Zhejiang

[19] Tongji Hospital

[20] Wuhan

[21] Hubei

[22] The First Affiliated Hospital of Bengbu Medical College

[23] Bengbu

[24] Affiliated Hospital of Nantong University

[25] Nantong

[26] Jiangsu

[27] The Hospital of Shunyi District Beijing

[28] Department of Infection and Immunology

[29] Tianjin Union Medical Center

[30] Tianjin

[31] Tianjin First Central Hospital

[32] Tianjin Medical University General Hospital

[33] Peace Hospital

[34] Shijiazhuang

[35] Hebei

[36] Hebei General Hospital

[37] Jiangxi Provincial People’s Hospital

[38] Nanchang

[39] Jiangxi

[40] Division of Rheumatology and Immunology

[41] The Second Xiangya Hospital of Central South University

[42] Changsha

[43] Hunan

[44] The First College of Clinical Medical Science of China Three Gorges University & Yichang Central People’s Hospital

[45] Yichang

[46] Department of Rheumatology and Immunology I Wald

[47] Xi’an No Hospital

[48] Xi’an

[49] Shaanxi

[50] Department of Rheumatology and Immunology V Wald

来源：

中华医学杂志英文版 | 2019年 / 132卷 / 24期

关键词：

Anti-cyclic citrullinated peptide antibody; Arthritis, Rheumatoid; Rheumatoid factor; Undifferentiated arthritis;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Background: Clinical outcomes of undifferentiated arthritis (UA) are diverse, and only 40% of patients with UA develop rheumatoid arthritis (RA) after 3 years. Discovering predictive markers at disease onset for further intervention is critical. Therefore, our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA development.Methods: We performed a prospective, multi-center study from January 2013 to October 2016 among Chinese patients diagnosed with UA in 22 tertiary-care hospitals. Clinical and serological parameters were obtained at recruitment. Follow-up was undertaken in all patients every 12 weeks for 2 years. Predictive factors of disease progression were identified using multivariate Cox proportional hazards regression.Results: A total of 234 patients were recruited in this study, and 17 (7.3%) patients failed to follow up during the study. Among the 217 patients who completed the study, 83 (38.2%) patients went into remission. UA patients who developed RA had a higher rheumatoid factor (RF)-positivity (42.9%vs. 16.8%, χ2 = 8.228,P = 0.008), anti-cyclic citrullinated peptide (CCP) antibodypositivity (66.7%vs. 10.7%, χ2 = 43.897,P < 0.001), and double-positivity rate of RF and anti-CCP antibody (38.1%vs. 4.1%, χ2 = 32.131,P < 0.001) than those who did not. Anti-CCP antibody but not RF was an independent predictor for RA development(hazard ratio 18.017, 95% confidence interval: 5.803–55.938;P < 0.001).Conclusion: As an independent predictor of RA, anti-CCP antibody should be tested at disease onset in all patients with UA.

引用

页码：2899 / 2904

页数：6

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