hsa-miR-1249和hsa-miR-486-5p与Ⅱ型糖尿病的相关性研究

被引：5

作者：

聂培培 ^{[1
]}

宫雅南 ^{[2
]}

机构：

[1] 广州医科大学金域检验学院

[2] 广州医科大学附属第二医院老年病科

来源：

激光生物学报 | 2016年 / 25卷 / 03期

基金：

广东省自然科学基金;

关键词：

microRNA; 基因芯片; Ⅱ型糖尿病; 标志物;

D O I：

暂无

中图分类号：

R587.1 [糖尿病];

学科分类号：

摘要：

microRNAs(miRNAs)是一类普遍存在于真核细胞的非编码小分子RNA,通常在转录后水平抑制靶基因的表达。miRNA表达失调与许多疾病相关,如Ⅱ型糖尿病(T2D)。Ⅱ型糖尿病是一种复杂的疾病,显著特征是高血糖。近年来的研究表明,miRNA在Ⅱ型糖尿病的发生发展中扮演着不同的角色。本研究通过miRNA微阵列芯片和实时荧光定量PCR的方法,发现hsa-miR-1249和hsa-miR-486-5p在Ⅱ型糖尿病患者血浆中较之于正常对照组表达显著降低,显示了hsa-miR-1249和hsa-miR-486-5p可能在Ⅱ型糖尿病的发病过程中起着重要的作用。本研究揭示了hsa-miR-1249和hsa-miR-486-5p有可能成为Ⅱ型糖尿病的新的诊断标志物和治疗靶标。

引用

页码：240 / 243

页数：4

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